Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50023093
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658997BDBM50658997(CHEMBL6169147)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to Hepatitis C virus genotype 1a NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336504BDBM50336504((2R,3aR,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to Hepatitis C virus genotype 1b NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336504BDBM50336504((2R,3aR,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to Hepatitis C virus genotype 1a NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25121BDBM25121(4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of GST-tagged human recombinant PLK1 (1 to 603 residues) extracted from baculovirus by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50402023BDBM50402023(BI 6727 | VOLASERTIB)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetVascular endothelial growth factor receptor 1(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658997BDBM50658997(CHEMBL6169147)
Affinity DataIC50: 3nMAssay Description:Inhibition of Hepatitis C virus genotype 1b NS3 proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658997BDBM50658997(CHEMBL6169147)
Affinity DataKi:  3nMAssay Description:Binding affinity to Hepatitis C virus genotype 1b NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336504BDBM50336504((2R,3aR,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Hepatitis C virus genotype 1b NS3 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 1517BDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataKi:  10nMAssay Description:Binding affinity to HCV NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 12311BDBM12311(SCH 503034 | (1R,5S)-N-[3-Amino-1-(cyclobutylmethy...)
Affinity DataKi:  14nMAssay Description:Binding affinity to HCV NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354624BDBM50354624(CHEMBL1834422 | US9951035, ND-322 (2) | US10357546...)
Affinity DataKi:  24nMAssay Description:Binding affinity to MMP2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 27nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 27nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 27nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 27nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 1517BDBM1517(CHEMBL37628 | 2-ethyl-7-methyl-2,4,9,15-tetraazatr...)
Affinity DataIC50: 30nMAssay Description:Inhibition of HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 1434BDBM1434(BI-RG-587 | 2-cyclopropyl-7-methyl-2,4,9,15-tetraa...)
Affinity DataIC50: 40nMAssay Description:Inhibition of HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658995BDBM50658995(CHEMBL6168538)
Affinity DataKd:  55nMAssay Description:Binding affinity to human full length N-terminal his-tagged CypA assessed as dissociation constant by calorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGenome polyprotein(Hepacivirus C)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658996BDBM50658996(CHEMBL6120459)
Affinity DataKi:  66nMAssay Description:Binding affinity to HCV NS3 protease assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50331094BDBM50331094(4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-meth...)
Affinity DataIC50: 85nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658995BDBM50658995(CHEMBL6168538)
Affinity DataKd:  131nMAssay Description:Binding affinity to KRAS G12V mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658995BDBM50658995(CHEMBL6168538)
Affinity DataKd:  364nMAssay Description:Binding affinity to KRAS G12D mutant (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Monash University (Malaysia Campus)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354624BDBM50354624(CHEMBL1834422 | US9951035, ND-322 (2) | US10357546...)
Affinity DataKi:  870nMAssay Description:Binding affinity to MMP9 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed