Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50000619
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255621BDBM50255621(CHEMBL4070624)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255603BDBM50255603(CHEMBL4083992)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255598BDBM50255598(CHEMBL4064004)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255566BDBM50255566(CHEMBL4094252)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255568BDBM50255568(CHEMBL4091768)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255581BDBM50255581(CHEMBL4073623)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255624BDBM50255624(CHEMBL4101983)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255622BDBM50255622(CHEMBL4067896)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255582BDBM50255582(CHEMBL4078783)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255583BDBM50255583(CHEMBL4096813)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255623BDBM50255623(CHEMBL4072758)
Affinity DataIC50: 1nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255581BDBM50255581(CHEMBL4073623)
Affinity DataEC50:  2nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255568BDBM50255568(CHEMBL4091768)
Affinity DataEC50:  2nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255585BDBM50255585(CHEMBL4094381)
Affinity DataIC50: 2nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255615BDBM50255615(CHEMBL4061204)
Affinity DataIC50: 5nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255584BDBM50255584(CHEMBL4089106)
Affinity DataIC50: 5nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255617BDBM50255617(CHEMBL4095468)
Affinity DataIC50: 10nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255566BDBM50255566(CHEMBL4094252)
Affinity DataEC50:  10nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255610BDBM50255610(CHEMBL4079884)
Affinity DataIC50: 12nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255618BDBM50255618(CHEMBL4104130)
Affinity DataIC50: 20nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255567BDBM50255567(CHEMBL4066892)
Affinity DataIC50: 30nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255604BDBM50255604(CHEMBL4093037)
Affinity DataIC50: 40nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255615BDBM50255615(CHEMBL4061204)
Affinity DataEC50:  63nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50152124BDBM50152124(CHEMBL3782004)
Affinity DataEC50:  126nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255620BDBM50255620(CHEMBL4083073)
Affinity DataIC50: 200nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255611BDBM50255611(CHEMBL4091375)
Affinity DataIC50: 200nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255567BDBM50255567(CHEMBL4066892)
Affinity DataEC50:  251nMAssay Description:Binding affinity to MTH1 in human K562 cells assessed as concentration required to achieve half of the maximal stabilization of protein at 54 degC af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255597BDBM50255597(CHEMBL4072600)
Affinity DataIC50: 300nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255596BDBM50255596(CHEMBL4065153)
Affinity DataIC50: 700nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255616BDBM50255616(CHEMBL4065372)
Affinity DataIC50: 1.40E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255612BDBM50255612(CHEMBL4070450)
Affinity DataIC50: 1.90E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255613BDBM50255613(CHEMBL4074252)
Affinity DataIC50: 2.50E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255609BDBM50255609(CHEMBL4069138)
Affinity DataIC50: 2.70E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255595BDBM50255595(CHEMBL4104536)
Affinity DataIC50: 3.00E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255619BDBM50255619(CHEMBL4094752)
Affinity DataIC50: 3.70E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255606BDBM50255606(CHEMBL4087765)
Affinity DataIC50: 5.60E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255608BDBM50255608(CHEMBL4096390)
Affinity DataIC50: 5.80E+3nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255614BDBM50255614(CHEMBL4087054)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255607BDBM50255607(CHEMBL4075035)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255605BDBM50255605(CHEMBL4066444)
Affinity DataIC50: 1.00E+4nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50255614BDBM50255614(CHEMBL4087054)
Affinity DataKd:  4.95E+4nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)