Compile Data Set for Download or QSAR
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Found 29 Enz. Inhib. hit(s) with all data for entry = 50009524
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084718((3,4-Dichloro-phenyl)-[4-(3,4-dichloro-phenyl)-4-h...)
Affinity DataKi:  10.9nMAssay Description:Binding Affinity to cocaine site of dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084718((3,4-Dichloro-phenyl)-[4-(3,4-dichloro-phenyl)-4-h...)
Affinity DataKi:  51nMAssay Description:Inhibition of [3H]-DA Uptake at dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  108nMAssay Description:Inhibition of [3H]-NE Uptake in rat parietal/occipital cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  155nMAssay Description:Inhibition of [3H]-5-HT Uptake in rat mid brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084718((3,4-Dichloro-phenyl)-[4-(3,4-dichloro-phenyl)-4-h...)
Affinity DataKi:  177nMAssay Description:Compound was tested for Inhibition of [3H]-NE Uptake in rat parietal/occipital cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  231nMAssay Description:Binding Affinity to Dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084717((+)-(1R,2R,3S,5S)-methyl 3-(benzoyloxy)-8-methyl-8...)
Affinity DataKi:  274nMAssay Description:Inhibition of [3H]-DA Uptake was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716((4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-to...)
Affinity DataKi:  360nMAssay Description:Inhibition of [3H]-DA Uptake at Dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716((4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-to...)
Affinity DataKi:  492nMAssay Description:Binding Affinity to cocaine site of Dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716((4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-to...)
Affinity DataKi:  1.63E+3nMAssay Description:Compound was tested for Inhibition of [3H]-5-HT Uptake in rat mid brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084718((3,4-Dichloro-phenyl)-[4-(3,4-dichloro-phenyl)-4-h...)
Affinity DataKi:  2.38E+3nMAssay Description:Compound was tested for Inhibition of [3H]-5-HT Uptake in rat mid brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084722((4-Hydroxy-1-methyl-4-phenyl-piperidin-3-yl)-pheny...)
Affinity DataKi:  2.59E+3nMAssay Description:Inhibition of [3H]-DA Uptake at Dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084720((2,4-Dichloro-phenyl)-[4-(2,4-dichloro-phenyl)-4-h...)
Affinity DataKi:  3.65E+3nMAssay Description:Binding Affinity to cocaine site of dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716((4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-to...)
Affinity DataKi:  3.86E+3nMAssay Description:Compound was tested for Inhibition of [3H]-NE Uptake in rat parietal/occipital cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084715(4-(3,4-Dichloro-phenyl)-3-[(3,4-dichloro-phenyl)-h...)
Affinity DataKi:  4.14E+3nMAssay Description:Binding Affinity to cocaine site of dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084714((4-Fluoro-phenyl)-[4-(4-fluoro-phenyl)-4-hydroxy-1...)
Affinity DataKi:  4.20E+3nMAssay Description:Inhibition of [3H]-DA Uptake at dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084715(4-(3,4-Dichloro-phenyl)-3-[(3,4-dichloro-phenyl)-h...)
Affinity DataKi:  4.22E+3nMAssay Description:Inhibition of [3H]-DA Uptake at dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084719(4-(2,4-Dichloro-phenyl)-3-[(2,4-dichloro-phenyl)-h...)
Affinity DataKi:  4.35E+3nMAssay Description:Binding Affinity to cocaine site of dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084722((4-Hydroxy-1-methyl-4-phenyl-piperidin-3-yl)-pheny...)
Affinity DataKi:  4.42E+3nMAssay Description:Binding Affinity to cocaine site of Dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084714((4-Fluoro-phenyl)-[4-(4-fluoro-phenyl)-4-hydroxy-1...)
Affinity DataKi:  5.70E+3nMAssay Description:Binding Affinity to cocaine site of dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084720((2,4-Dichloro-phenyl)-[4-(2,4-dichloro-phenyl)-4-h...)
Affinity DataKi:  5.85E+3nMAssay Description:Inhibition of [3H]-DA Uptake at dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084719(4-(2,4-Dichloro-phenyl)-3-[(2,4-dichloro-phenyl)-h...)
Affinity DataKi:  7.52E+3nMAssay Description:Inhibition of [3H]-DA Uptake at dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084724(6-Methyl-4,8a-di-p-tolyl-hexahydro-[1,3]dioxino[5,...)
Affinity DataKi:  8.19E+3nMAssay Description:Binding Affinity to cocaine site of dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084724(6-Methyl-4,8a-di-p-tolyl-hexahydro-[1,3]dioxino[5,...)
Affinity DataKi:  9.48E+3nMAssay Description:Inhibition of [3H]-DA Uptake at dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084723(3-(Hydroxy-p-tolyl-methyl)-1-methyl-4-p-tolyl-pipe...)
Affinity DataKi:  1.07E+4nMAssay Description:Binding Affinity to cocaine site of dopamine transporter in caudate nuclei which was homogenized and incubated with [3H]-mazindol .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084723(3-(Hydroxy-p-tolyl-methyl)-1-methyl-4-p-tolyl-pipe...)
Affinity DataKi:  1.58E+4nMAssay Description:Inhibition of [3H]-DA Uptake at dopamine transporter in rat cortex was measured by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716((4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-to...)
Affinity DataIC50:  470nMAssay Description:Antagonism of cocaine''s inhibition of [3H]-DA uptake at the dose of 50 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716((4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-to...)
Affinity DataIC50:  717nMAssay Description:Antagonism of cocaine''s inhibition of [3H]-DA uptake at the dose of 200 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50084716((4-Hydroxy-1-methyl-4-p-tolyl-piperidin-3-yl)-p-to...)
Affinity DataIC50:  1.16E+3nMAssay Description:Antagonism of cocaine''s inhibition of [3H]-DA uptake at the dose of 500 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed