Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50017194
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178912BDBM50178912(9-cyclopropyl-6-fluoro-7-(pyridin-3-yl)isothiazolo...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178913BDBM50178913(7-(6-(aminomethyl)pyridin-3-yl)-9-cyclopropyl-6-fl...)
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131428BDBM50131428(CHEMBL32 | 1-Cyclopropyl-6-fluoro-8-methoxy-7-(oct...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21690BDBM21690(Ciprinol | 1-cyclopropyl-6-fluoro-4-oxo-7-(piperaz...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178914BDBM50178914(9-cyclopropyl-6-fluoro-7-(5-(pyrrolidin-2-yl)pyrid...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178892BDBM50178892(9-cyclopropyl-6-fluoro-7-(pyridin-4-yl)isothiazolo...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178905BDBM50178905(9-cyclopropyl-6-fluoro-7-(2-fluoropyridin-3-yl)iso...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178894BDBM50178894(9-cyclopropyl-6-fluoro-7-(quinolin-6-yl)isothiazol...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178904BDBM50178904(9-cyclopropyl-6-fluoro-7-(1H-indol-2-yl)isothiazol...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178884BDBM50178884(9-cyclopropyl-6-fluoro-7-(pyrimidin-5-yl)isothiazo...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178897BDBM50178897(9-cyclopropyl-6-fluoro-7-(2-methoxypyrimidin-5-yl)...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178882BDBM50178882(9-cyclopropyl-6-fluoro-7-(2-methylpyridin-3-yl)iso...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178878BDBM50178878(9-cyclopropyl-6-fluoro-7-(isoquinolin-6-yl)isothia...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178909BDBM50178909(9-cyclopropyl-6-fluoro-7-(1-methyl-1H-indol-5-yl)i...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178907BDBM50178907(9-cyclopropyl-6-fluoro-7-(2-(hydroxymethyl)pyridin...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178910BDBM50178910(9-cyclopropyl-6-fluoro-7-(5-(piperidin-2-yl)pyridi...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178915BDBM50178915(9-cyclopropyl-6-fluoro-7-phenylisothiazolo[5,4-b]q...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178888BDBM50178888(9-cyclopropyl-7-(2,6-dimethylpyridin-3-yl)-6-fluor...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178902BDBM50178902(9-cyclopropyl-6-fluoro-7-(6-methylpyridin-3-yl)iso...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178886BDBM50178886(9-cyclopropyl-6-fluoro-7-(1H-pyrrol-2-yl)isothiazo...)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178896BDBM50178896(9-cyclopropyl-6-fluoro-7-(4-methoxypyridin-3-yl)is...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178900BDBM50178900(9-cyclopropyl-6-fluoro-7-(6-fluoropyridin-3-yl)iso...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178908BDBM50178908(9-cyclopropyl-6-fluoro-7-(5-methylpyridin-2-yl)iso...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178899BDBM50178899(9-cyclopropyl-6-fluoro-7-(4-methylpyridin-2-yl)iso...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178881BDBM50178881(9-cyclopropyl-7-(2,6-dimethoxypyridin-3-yl)-6-fluo...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178890BDBM50178890(7-(6-(1H-pyrrol-1-yl)pyridin-3-yl)-9-cyclopropyl-6...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178880BDBM50178880(9-cyclopropyl-6-fluoro-7-(2-fluoropyridin-4-yl)iso...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178891BDBM50178891(9-cyclopropyl-6-fluoro-7-(5-methoxypyridin-3-yl)is...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178903BDBM50178903(9-cyclopropyl-6-fluoro-7-(isoquinolin-5-yl)isothia...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178906BDBM50178906(9-cyclopropyl-6-fluoro-7-(2-methylpyridin-4-yl)iso...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178898BDBM50178898(9-cyclopropyl-6-fluoro-7-(6-methoxypyridin-3-yl)is...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178883BDBM50178883(9-cyclopropyl-6-fluoro-7-(quinazolin-7-yl)isothiaz...)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178885BDBM50178885(9-cyclopropyl-6-fluoro-7-(quinolin-5-yl)isothiazol...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178893BDBM50178893(9-cyclopropyl-6-fluoro-7-(isoquinolin-4-yl)isothia...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178901BDBM50178901(9-cyclopropyl-6-fluoro-7-(1H-indol-5-yl)isothiazol...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178895BDBM50178895(9-cyclopropyl-6-fluoro-7-(quinolin-8-yl)isothiazol...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178889BDBM50178889(9-cyclopropyl-7-(2,4-dimethoxypyrimidin-5-yl)-6-fl...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178879BDBM50178879(9-cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6-fluor...)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178887BDBM50178887(9-cyclopropyl-6-fluoro-7-(quinolin-3-yl)isothiazol...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Achillion Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178911BDBM50178911(9-cyclopropyl-6-fluoro-7-(pyrazin-2-yl)isothiazolo...)
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed