Compile Data Set for Download or QSAR
Report error Found 76 Enz. Inhib. hit(s) with all data for entry = 50019162
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataKi:  0.0380nMAssay Description:Competitive inhibition of soluble C-terminal 6His-tagged recombinant human CD73 (27 to 547 residues) expressed in CHO cells assessed as inhibition co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CD73 in human plasma derived from esophageal cancer patient incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511079BDBM511079(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataKi:  0.110nMAssay Description:Competitive inhibition of cell surface anchored CD73 (unknown origin) expressed in human SK-MEL-28 cells assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of CD73 in human plasma derived from ovarian cancer patient incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of CD73 in human plasma derived from TNBC cancer patient incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511125BDBM511125(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of CD73 in human plasma derived from HNSCC cancer patient incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511077BDBM511077(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511077BDBM511077(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of CD73 in human plasma incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511124BDBM511124(2-([1,1′-biphenyl]-4-ylmethyl)-2-(((2R,3S,4R...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511087BDBM511087(2-benzyl-2-(((2R,3S,4R,5R)-5-(2-chloro-6-(thiophen...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of CD73 in human plasma incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511079BDBM511079(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of CD73 in human plasma incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511070BDBM511070(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511111BDBM511111(2-benzyl-2-(((2R,3S,4R,5R)-5-(2-chloro-6-(3-hydrox...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615993BDBM50615993(CHEMBL5417110)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615991BDBM50615991(CHEMBL5435185)
Affinity DataIC50: 1nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511069BDBM511069(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615994BDBM50615994(CHEMBL5419527)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615996BDBM50615996(CHEMBL5409033)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615998BDBM50615998(CHEMBL5404795)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of CD73 in mouse plasma incubated for 5 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511076BDBM511076(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant mouse CD73 (29 to 549 residues) expressed in CHO cells incubated for 1 hr by malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511070BDBM511070(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511069BDBM511069(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435848BDBM435848(US10570167, Cpd. # 174 | US11034715, Cpd. # 174 | ...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615992BDBM50615992(CHEMBL5423764)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511093BDBM511093(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511099BDBM511099(2-benzyl-2-(((2R,3S,4R,5R)-5-(5-chloro-7-(isopropy...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615995BDBM50615995(CHEMBL5410317)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615997BDBM50615997(CHEMBL5404674)
Affinity DataIC50: 2nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511100BDBM511100(2-benzyl-2-(((2R,3S,4R,5R)-5-(5-chloro-7-(isopropy...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435848BDBM435848(US10570167, Cpd. # 174 | US11034715, Cpd. # 174 | ...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511125BDBM511125(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of CD73 in human plasma incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511071BDBM511071(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511218BDBM511218(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 5nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511111BDBM511111(2-benzyl-2-(((2R,3S,4R,5R)-5-(2-chloro-6-(3-hydrox...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of CD73 in human plasma incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435848BDBM435848(US10570167, Cpd. # 174 | US11034715, Cpd. # 174 | ...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of CD73 in human plasma incubated for 15 mins in presence of 15N5-AMP by LC/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511148BDBM511148(2-benzyl-2-(((2R,3S,4R,5R)-5-(2-chloro-6-(methylam...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511205BDBM511205(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615991BDBM50615991(CHEMBL5435185)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615990BDBM50615990(CHEMBL5425274)
Affinity DataIC50: 7nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615997BDBM50615997(CHEMBL5404674)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Mouse)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435848BDBM435848(US10570167, Cpd. # 174 | US11034715, Cpd. # 174 | ...)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant mouse CD73 (29 to 549 residues) expressed in CHO cells incubated for 1 hr by malachite green assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511073BDBM511073(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 8nMAssay Description:Inhibition of bovine CA4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615999BDBM50615999(CHEMBL5403031)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human CD73More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target5'-nucleotidase(Human)
Calithera Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 511203BDBM511203(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human CA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
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