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Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50021524
LigandPNGBDBM50622941(CHEMBL5417338)
Affinity DataKd:  18nMAssay Description:Binding affinity to full-length human recombinant NLRP3 assessed as dissociation constant incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM50622941(CHEMBL5417338)
Affinity DataKd:  25nMAssay Description:Binding affinity to full-length mouse recombinant NLRP3 assessed as dissociation constant by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50622948(CHEMBL5434916 | US20250243172, Compound Formula X ...)
Affinity DataKd:  55nMAssay Description:Binding affinity to full-length human recombinant NLRP3 assessed as dissociation constant incubated for 30 mins by microscale thermophoresis assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641561(CHEMBL5594402)
Affinity DataIC50: 510nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
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Date in BDB:
TBA
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LigandPNGBDBM50622941(CHEMBL5417338)
Affinity DataIC50: 550nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641565(CHEMBL5574659)
Affinity DataIC50: 810nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641564(CHEMBL5570770)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50622942(CHEMBL5400432)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50622945(CHEMBL5435765)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50622944(CHEMBL5402231 | US20250243172, Compound Formula VI...)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641563(CHEMBL5566562)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641548(CHEMBL5575446)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641553(CHEMBL5563592)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641557(CHEMBL5571716)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641556(CHEMBL5575825)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM50622948(CHEMBL5434916 | US20250243172, Compound Formula X ...)
Affinity DataIC50: 2.09E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641559(CHEMBL5564356)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50622947(CHEMBL5430191 | US20250243172, Compound Formula IX...)
Affinity DataIC50: 2.31E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641567(CHEMBL5571686)
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641566(CHEMBL5571863)
Affinity DataIC50: 2.86E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641560(CHEMBL5575752)
Affinity DataIC50: 3.13E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641558(CHEMBL5575099)
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641555(CHEMBL5575631)
Affinity DataIC50: 4.21E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641550(CHEMBL5564692)
Affinity DataIC50: 4.28E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641562(CHEMBL5572709)
Affinity DataIC50: 8.06E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641551(CHEMBL5574485)
Affinity DataIC50: 8.36E+3nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641552(CHEMBL5571058)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641549(CHEMBL5573002)
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50641554(CHEMBL5570346)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS treated mouse J774.A1 cells assessed as inhibition of ATP-stimulated IL-1beta secretion pre-incuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details