Compile Data Set for Download or QSAR
maximum 50k data
Found 50 Enz. Inhib. hit(s) with all data for entry = 50027491
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25162(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)thiophen-2...)
Affinity DataIC50:  130nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25159(CHEMBL462208 | N-[(1S)-1-phenylethyl]-5-(2,2,2-tri...)
Affinity DataIC50:  150nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50:  170nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50:  175nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275675(CHEMBL519738 | N-(2-chlorobenzyl)-5-(2,2,2-trifluo...)
Affinity DataIC50:  190nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25157(CHEMBL462209 | N-benzyl-N-methyl-5-(2,2,2-trifluor...)
Affinity DataIC50:  230nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(CHEMBL485968 | N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-...)
Affinity DataIC50:  260nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25164(2,2,2-trifluoro-1-[5-({3-phenyl-5H,6H,7H,8H-imidaz...)
Affinity DataIC50:  310nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(CHEMBL485967 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2...)
Affinity DataIC50:  360nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275676(2,2,2-trifluoro-1-(2-(indoline-1-carbonyl)thiazol-...)
Affinity DataIC50:  410nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275675(CHEMBL519738 | N-(2-chlorobenzyl)-5-(2,2,2-trifluo...)
Affinity DataIC50:  550nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25157(CHEMBL462209 | N-benzyl-N-methyl-5-(2,2,2-trifluor...)
Affinity DataIC50:  560nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50:  580nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25184(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)-1H-pyrrol...)
Affinity DataIC50:  580nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  650nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25163(CHEMBL497332 | N-methyl-N-(quinoxalin-6-ylmethyl)-...)
Affinity DataIC50:  670nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(CHEMBL485967 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2...)
Affinity DataIC50:  830nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(CHEMBL485967 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2...)
Affinity DataIC50:  840nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25157(CHEMBL462209 | N-benzyl-N-methyl-5-(2,2,2-trifluor...)
Affinity DataIC50:  890nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25162(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)thiophen-2...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(CHEMBL485967 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25162(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)thiophen-2...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(CHEMBL485968 | N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275676(2,2,2-trifluoro-1-(2-(indoline-1-carbonyl)thiazol-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(CHEMBL485968 | N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(CHEMBL485968 | N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275677(CHEMBL519739 | N-(cyclohexylmethyl)-5-(2,2,2-trifl...)
Affinity DataIC50:  3.32E+3nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25164(2,2,2-trifluoro-1-[5-({3-phenyl-5H,6H,7H,8H-imidaz...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25164(2,2,2-trifluoro-1-[5-({3-phenyl-5H,6H,7H,8H-imidaz...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25159(CHEMBL462208 | N-[(1S)-1-phenylethyl]-5-(2,2,2-tri...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50246037(2,2,2-trifluoro-1-(5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275603(2,2,2-trifluoro-1-(5-(4-(3-methoxyphenyl)piperazin...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25159(CHEMBL462208 | N-[(1S)-1-phenylethyl]-5-(2,2,2-tri...)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275639(1-(5-(4-(5-chloro-2-methoxyphenyl)piperazine-1-car...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(CHEMBL485968 | N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(CHEMBL485967 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275641(CHEMBL485968 | N-(1-(pyridin-4-yl)ethyl)-5-(2,2,2-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275640(CHEMBL485967 | N-(1-(naphthalen-1-yl)ethyl)-5-(2,2...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed