Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50028702
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249854BDBM50249854(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human MDR1 expressed in HEK cells assessed as [3H]vinblastine transport after 2.5 mins by scintillation countMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249649BDBM50249649(Dimethyl-(8-phenyl-2,3,5,6-tetrahydro-1H,4H-13-sel...)
Affinity DataIC50: 280nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249854BDBM50249854(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50: 670nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50423653BDBM50423653(CHEMBL2087786)
Affinity DataIC50: 930nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249854BDBM50249854(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249649BDBM50249649(Dimethyl-(8-phenyl-2,3,5,6-tetrahydro-1H,4H-13-sel...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249906BDBM50249906(3,6-Bis(N,N-dimethylamino)-9-(2-thienyl-5-carboxam...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249648BDBM50249648(Dimethyl-(8-phenyl-2,3,5,6-tetrahydro-1H,4H-13-thi...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249649BDBM50249649(Dimethyl-(8-phenyl-2,3,5,6-tetrahydro-1H,4H-13-sel...)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249853BDBM50249853(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249855BDBM50249855(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249730BDBM50249730(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(4-N,N-dim...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249818BDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249852BDBM50249852(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249852BDBM50249852(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246356BDBM50246356(N-(6-(dimethylamino)-9-phenyl-3H-selenoxanthen-3-y...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50246355BDBM50246355(N-(6-(dimethylamino)-9-phenyl-3H-thioxanthen-3-yli...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249853BDBM50249853(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249856BDBM50249856(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-piperid...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249858BDBM50249858(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-morphol...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50338982BDBM50338982((R)-5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249648BDBM50249648(Dimethyl-(8-phenyl-2,3,5,6-tetrahydro-1H,4H-13-thi...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249818BDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249857BDBM50249857(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(N-morphol...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human MDR1 expressed in MDCK2 cells assessed as enhancement of Calcein-AM uptake treated 30 mins before Calcein-AM challenge measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249698BDBM50249698(N-(6-(dimethylamino)-9-(4-(dimethylamino)phenyl)-3...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249768BDBM50249768(N-(6-(dimethylamino)-9-(4-morpholinophenyl)-3H-sel...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249749BDBM50249749(12-(Dimethylamino)-2,3,6,7-tetrahydro-9-(3-N,N-dim...)
Affinity DataIC50: 2.36E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249818BDBM50249818(3,6-Bis(dimethylamino)-9-(N-piperidyl-2-thienyl-5-...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Mouse)
The State University of New York

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50249817BDBM50249817(N-(9-(5-carboxythiophen-2-yl)-6-(dimethylamino)-3H...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of verapamil-stimulated ATPase activity of mouse cysteine-less MDR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed