Compile Data Set for Download or QSAR
Report error Found 73 Enz. Inhib. hit(s) with all data for entry = 50031440
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313312BDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  0.600nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313338BDBM50313338(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(2-methyl...)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313339BDBM50313339(6-(cyclohexyl(propyl)amino)-N-(2-methyl-4-sulfamoy...)
Affinity DataEC50:  2.90nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313357BDBM50313357(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313312BDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at S1P1 receptor expressed in human U20S cells assessed as receptor internalization by green fluorescent protein reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313312BDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313343BDBM50313343(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(2-methyl...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313353BDBM50313353(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313363BDBM50313363(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313351BDBM50313351(6-(dipropylamino)-N-(1H-indazol-5-yl)pyrimidine-4-...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313350BDBM50313350(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(1H-indaz...)
Affinity DataEC50:  9nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313355BDBM50313355(2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313354BDBM50313354(6-((cyclopropylmethyl)(propyl)amino)-N-(6-methyl-1...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313311BDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at S1P1 receptor expressed in human U20S cells assessed as receptor internalization by green fluorescent protein reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313311BDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313363BDBM50313363(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  19nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313359BDBM50313359(4-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313323BDBM50313323(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-hydrox...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313358BDBM50313358(3-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidi...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313361BDBM50313361(2-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313340BDBM50313340(6-(dipropylamino)-N-(2-methyl-4-sulfamoylphenyl)py...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313344BDBM50313344(N-(4-(aminomethyl)phenyl)-6-(cyclohexyl(cyclopropy...)
Affinity DataEC50:  39nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313357BDBM50313357(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  62nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313337BDBM50313337(6-(cyclohexyl(methyl)amino)-N-(2-methyl-4-sulfamoy...)
Affinity DataEC50:  65nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313342BDBM50313342(N-(4-carbamoylphenyl)-6-(cyclohexyl(cyclopropylmet...)
Affinity DataEC50:  73nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313362BDBM50313362(2-((4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrim...)
Affinity DataEC50:  94nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313338BDBM50313338(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(2-methyl...)
Affinity DataEC50:  96nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313345BDBM50313345(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-((dime...)
Affinity DataEC50:  104nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313357BDBM50313357(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  114nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313311BDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)
Affinity DataEC50:  142nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313323BDBM50313323(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-hydrox...)
Affinity DataEC50:  191nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313341BDBM50313341(6-(cyclohexyl(cyclopropylmethyl)amino)-N-(4-(methy...)
Affinity DataEC50:  193nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313356BDBM50313356(2-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidi...)
Affinity DataEC50:  208nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313352BDBM50313352(6-(cyclohexyl(methyl)amino)-N-(6-methyl-1H-indazol...)
Affinity DataEC50:  211nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313312BDBM50313312(1-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  236nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313360BDBM50313360(4-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidi...)
Affinity DataEC50:  238nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313325BDBM50313325(6-(Cyclohexylamino)-N-(4-hydroxy-2-methylphenyl)py...)
Affinity DataEC50:  258nMAssay Description:Agonist activity at S1P5 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313324BDBM50313324(6-(dipropylamino)-N-(4-hydroxyphenyl)pyrimidine-4-...)
Affinity DataEC50:  375nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313328BDBM50313328(6-(cyclohexylamino)-N-(4-hydroxy-2-(trifluoromethy...)
Affinity DataEC50:  382nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313327BDBM50313327(N-(2-chloro-4-hydroxyphenyl)-6-(cyclohexylamino)py...)
Affinity DataEC50:  390nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313322BDBM50313322(6-(cyclohexyl(ethyl)amino)-N-(4-hydroxy-2-methylph...)
Affinity DataEC50:  405nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313311BDBM50313311(6-((cyclopropylmethyl)(propyl)amino)-N-(1H-indazol...)
Affinity DataEC50:  416nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313347BDBM50313347(6-(cyclohexyl(methyl)amino)-N-(1H-indazol-5-yl)pyr...)
Affinity DataEC50:  418nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313326BDBM50313326(6-(cyclohexylamino)-N-(2-fluoro-4-hydroxyphenyl)py...)
Affinity DataEC50:  440nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313336BDBM50313336(6-(cyclohexylamino)-N-(2-methyl-4-sulfamoylphenyl)...)
Affinity DataEC50:  440nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313321BDBM50313321(6-(cyclohexyl(methyl)amino)-N-(4-hydroxy-2-methylp...)
Affinity DataEC50:  655nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313320BDBM50313320(6-(cyclohexyl(methyl)amino)-N-(4-hydroxyphenyl)pyr...)
Affinity DataEC50:  700nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313333BDBM50313333(6-(cyclohexylamino)-N-(4-(methylsulfonamido)phenyl...)
Affinity DataEC50:  960nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313319BDBM50313319(6-(cycloheptylamino)-N-(4-hydroxy-2-methylphenyl)p...)
Affinity DataEC50:  973nMAssay Description:Agonist activity at S1P1 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Merck Serono

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313363BDBM50313363(3-(4-(6-(cyclohexyl(cyclopropylmethyl)amino)pyrimi...)
Affinity DataEC50:  1.09E+3nMAssay Description:Agonist activity at S1P3 receptor expressed in CHO cells after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
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