Compile Data Set for Download or QSAR
maximum 50k data
Found 68 Enz. Inhib. hit(s) with all data for entry = 50032256
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM22910(4-(1H-imidazol-5-ylmethyl)pyridine | Immethridine)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326285((S)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataKi:  17nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  48nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326288(3-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326293(2-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326297(3-((1H-imidazol-4-yl)methyl)pyridine | 3-(3H-Imida...)
Affinity DataKi:  76nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326294(3-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326295(4-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326285((S)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  280nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  310nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326288(3-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  360nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326292(4-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  530nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataKi:  540nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi:  840nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326291(3-(4-tert-Butylphenylthio)-2-(1H-imidazol-4-yl)-N-...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326290(2-(1H-Imidazol-4-yl)-N-methyl-3-(4-(trifluoromethy...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326285((S)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity to human histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326296(2-((1H-imidazol-4-yl)methyl)pyridine | 2-(3H-Imida...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326288(3-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326288(3-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326285((S)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataIC50:  55nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50:  270nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataIC50:  350nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataIC50:  470nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataIC50:  680nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50317865(2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole |...)
Affinity DataIC50:  680nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50:  820nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326292(4-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326292(4-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326287(2-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326292(4-(2-(4-tert-Butylphenylthio)-1-(1H-imidazol-4-yl)...)
Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326289(4-(1-(1H-Imidazole-4-yl)-2-(4-trifluoromeethylphen...)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Meiji Seika Kaisha

Curated by ChEMBL
LigandPNGBDBM50326286((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Affinity DataIC50: >9.40E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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