Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50035294
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001786BDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127999BDBM50127999(1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3-yl]-piperi...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001778BDBM50001778((Lu 23-086)1-(2-{4-[1-(4-Fluoro-phenyl)-1H-indol-3...)
Affinity DataIC50: 7nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002002BDBM50002002(CHEMBL12186 | 1-(2-{4-[5-Chloro-1-(4-fluoro-phenyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50031720BDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataIC50: 10nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053194BDBM50053194([5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-ylmethyl]...)
Affinity DataIC50: 11nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50334150BDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50: 18nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127982BDBM50127982(1-(2-{4-[1-(4-Fluoro-phenyl)-2,3-dihydro-1H-indol-...)
Affinity DataIC50: 24nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21398BDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: 32nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50128003BDBM50128003(MK-499 | N-[1'-(6-cyano-1,2,3,4-tetrahydro-2-napht...)
Affinity DataIC50: 34nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127983BDBM50127983(4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethy...)
Affinity DataIC50: 36nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005836BDBM50005836(4-amino-5-chloro-N-(1-(3-(4-fluorophenoxy)propyl)-...)
Affinity DataIC50: 45nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50017376BDBM50017376(1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl...)
Affinity DataIC50: 56nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127989BDBM50127989(1-{2-[4-(5-Chloro-1-phenyl-1H-indol-3-yl)-piperidi...)
Affinity DataIC50: 88nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50128000BDBM50128000([4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-eth...)
Affinity DataIC50: 131nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50128001BDBM50128001(1-{2-[4-(5-Chloro-1-cyclohexyl-1H-indol-3-yl)-pipe...)
Affinity DataIC50: 137nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 81939BDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 143nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50002009BDBM50002009(CHEMBL273235 | 5-Chloro-1-(4-fluoro-phenyl)-3-pipe...)
Affinity DataIC50: 204nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127988BDBM50127988(4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-1-[...)
Affinity DataIC50: 460nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127992BDBM50127992([4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-eth...)
Affinity DataIC50: 579nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127986BDBM50127986(5-Chloro-3-(1-ethyl-propyl)-1-(4-fluoro-phenyl)-1H...)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127984BDBM50127984(1-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-pro...)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127998BDBM50127998(1-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-pro...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127987BDBM50127987(5-Chloro-3-ethyl-1-(4-fluoro-phenyl)-1H-indole | C...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127994BDBM50127994(1-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-eth...)
Affinity DataIC50: 4.55E+3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127991BDBM50127991(5-Chloro-1-(4-fluoro-phenyl)-3-isopropyl-1H-indole...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127990BDBM50127990(5-tert-Butyl-1-(4-fluoro-phenyl)-1H-indole | CHEMB...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127995BDBM50127995(1-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-eth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127997BDBM50127997(3-[5-Chloro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-pen...)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22874BDBM22874(CHEMBL914 | Allegra | 2-(4-{1-hydroxy-4-[4-(hydrox...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50128002BDBM50128002(5-Chloro-1-(4-fluoro-phenyl)-3-propyl-1H-indole | ...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Aventis Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50127996BDBM50127996(4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethy...)
Affinity DataIC50: 7.50E+4nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2012
Entry Details Article
PubMed