Compile Data Set for Download or QSAR
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Found 42 Enz. Inhib. hit(s) with all data for entry = 50035364
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125195((S)-2-(2-Bromo-benzoylamino)-3-(3H-imidazol-4-yl)-...)
Affinity DataIC50:  750nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125215((S)-2-(2-Bromo-benzoylamino)-succinamic acid | CHE...)
Affinity DataIC50:  1.08E+3nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125208((S)-2-(2-Bromo-benzoylamino)-3-(4-hydroxy-phenyl)-...)
Affinity DataIC50:  1.09E+3nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125221((S)-6-Amino-2-(2-bromo-benzoylamino)-hexanoic acid...)
Affinity DataIC50:  1.21E+3nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125228((S)-2-(2-Bromo-benzoylamino)-3-(1H-indol-3-yl)-pro...)
Affinity DataIC50:  1.70E+3nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125194((S)-2-(2-Bromo-benzoylamino)-4-carbamoyl-butyric a...)
Affinity DataIC50:  1.77E+3nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125232((S)-2-(2-Bromo-benzoylamino)-5-guanidino-pentanoic...)
Affinity DataIC50:  2.71E+3nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125196((S)-2-(2-Bromo-benzoylamino)-3-(5-methoxy-1H-indol...)
Affinity DataIC50:  2.77E+3nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50366858(CHEMBL1793834)
Affinity DataIC50:  3.84E+3nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125220((R)-2-(2-Bromo-benzoylamino)-3-mercapto-propionic ...)
Affinity DataIC50:  4.26E+3nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125217((S)-2-(2-Bromo-benzoylamino)-3-phenyl-propionic ac...)
Affinity DataIC50:  4.89E+3nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125206((S)-2-(2-Bromo-benzoylamino)-4-phenyl-butyric acid...)
Affinity DataIC50:  5.09E+3nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125198((S)-2-(2-Bromo-benzoylamino)-3-thiophen-2-yl-propi...)
Affinity DataIC50:  5.50E+3nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125212((S)-2-(2-Bromo-benzoylamino)-3-hydroxy-propionic a...)
Affinity DataIC50:  6.15E+3nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125204((S)-2-(2-Bromo-benzoylamino)-propionic acid | CHEM...)
Affinity DataIC50:  6.64E+3nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125218((S)-2-(2-Bromo-benzoylamino)-4-methylsulfanyl-buty...)
Affinity DataIC50:  7.46E+3nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125233((S)-2-(2-Bromo-benzoylamino)-3-(6-fluoro-1H-indol-...)
Affinity DataIC50:  7.64E+3nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125219((S)-2-(2-Bromo-benzoylamino)-3-(5-fluoro-1H-indol-...)
Affinity DataIC50:  1.08E+4nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125229((S)-2-(2-Bromo-benzoylamino)-3-methyl-butyric acid...)
Affinity DataIC50:  1.13E+4nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125235((S)-2-(2-Bromo-benzoylamino)-3-naphthalen-1-yl-pro...)
Affinity DataIC50:  1.60E+4nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125227((S)-2-(2-Bromo-benzoylamino)-3-(5-hydroxy-1H-indol...)
Affinity DataIC50:  2.42E+4nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125201((S)-2-(2-Bromo-benzoylamino)-3-naphthalen-2-yl-pro...)
Affinity DataIC50:  2.44E+4nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125197((S)-2-(2-Bromo-benzoylamino)-3-(5-bromo-1H-indol-3...)
Affinity DataIC50:  2.84E+4nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125202((S)-2-(2-Bromo-benzoylamino)-pentanedioic acid | C...)
Affinity DataIC50:  3.01E+4nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125230((S)-2-(2-Bromo-benzoylamino)-3-(4-cyano-phenyl)-pr...)
Affinity DataIC50:  3.68E+4nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125231((S)-3-Biphenyl-4-yl-2-(2-bromo-benzoylamino)-propi...)
Affinity DataIC50:  5.05E+4nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125224((S)-2-(2-Bromo-benzoylamino)-4-methyl-pentanoic ac...)
Affinity DataIC50:  5.43E+4nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125205((R)-2-(2-Bromo-benzoylamino)-propionic acid | CHEM...)
Affinity DataIC50:  5.75E+4nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125216((S)-2-(2-Bromo-benzoylamino)-3-(1H-pyrrolo[2,3-b]p...)
Affinity DataIC50:  6.38E+4nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125214((R)-2-(2-Bromo-benzoylamino)-3-hydroxy-propionic a...)
Affinity DataIC50:  7.26E+4nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125234((R)-2-(2-Bromo-benzoylamino)-3-(1H-indol-3-yl)-pro...)
Affinity DataIC50:  7.66E+4nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125210((2S,3S)-2-(2-Bromo-benzoylamino)-3-methyl-pentanoi...)
Affinity DataIC50:  1.06E+5nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125225(2-Bromo-N-[(S)-1-hydroxycarbamoyl-2-(1H-indol-3-yl...)
Affinity DataIC50:  1.40E+5nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125209((S)-2-(2-Bromo-benzoylamino)-succinic acid | CHEMB...)
Affinity DataIC50: >2.00E+5nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125207((R)-2-(2-Bromo-benzoylamino)-3-naphthalen-1-yl-pro...)
Affinity DataIC50: >2.00E+5nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125223((R)-2-(2-Bromo-benzoylamino)-3-naphthalen-2-yl-pro...)
Affinity DataIC50:  2.43E+5nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125222((R)-2-(2-Bromo-benzoylamino)-3-phenyl-propionic ac...)
Affinity DataIC50:  2.80E+5nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125199((2-Bromo-benzoylamino)-acetic acid | CHEMBL7664)
Affinity DataIC50:  3.14E+5nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125211((S)-1-(2-Bromo-benzoyl)-pyrrolidine-2-carboxylic a...)
Affinity DataIC50: >1.00E+6nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125200((S)-2-(2-Bromo-benzoylamino)-3-(1H-indol-3-yl)-pro...)
Affinity DataIC50: >1.00E+6nMAssay Description:In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125213(2-Bromo-N-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl...)
Affinity DataIC50: >1.00E+6nMAssay Description:Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50125203(2-Bromo-N-[2-(1H-indol-3-yl)-ethyl]-benzamide | CH...)
Affinity DataIC50: >1.00E+6nMAssay Description:In vitro inhibitory potency for preventing sarafotoxin S6c induced constriction of rat tracheal rings (ETB receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed