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Found 80 Enz. Inhib. hit(s) with all data for entry = 50037640
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  0.160nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Affinity DataIC50:  0.190nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174029((E)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174018((E)-N-isopropyl-3-(3-(6-isopropylquinolin-8-yl)phe...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174013((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174018((E)-N-isopropyl-3-(3-(6-isopropylquinolin-8-yl)phe...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174013((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174023((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174021((Z)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Affinity DataIC50:  0.470nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174015((E)-N-isopropyl-2-(4-(methylsulfonyl)phenyl)-3-(3-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174013((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174023((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174021((Z)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022((E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174018((E)-N-isopropyl-3-(3-(6-isopropylquinolin-8-yl)phe...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174023((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174029((E)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174029((E)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174015((E)-N-isopropyl-2-(4-(methylsulfonyl)phenyl)-3-(3-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174021((Z)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174026((Z)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174027(2-(2-(2-(3-(6-(1-(methylsulfonyl)ethyl)quinolin-8-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022((E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022((E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174017(8-(3-(2-(3-methylcyclopenta-1,3-dienyl)-2-(4-(meth...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174027(2-(2-(2-(3-(6-(1-(methylsulfonyl)ethyl)quinolin-8-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174014(4-(3-(6-isopropylquinolin-8-yl)phenyl)-2-methyl-3-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174026((Z)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174016(CHEMBL370220 | N-(3-(6-(pyridin-4-ylmethyl)quinoli...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174027(2-(2-(2-(3-(6-(1-(methylsulfonyl)ethyl)quinolin-8-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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