Compile Data Set for Download or QSAR
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Found 31 Enz. Inhib. hit(s) with all data for entry = 50005971
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043224(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043221(3-Mercapto-6-methyl-4-(1-methylcarbamoyl-2-phenyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043231(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043228(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043227(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043237(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043222(4-(2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043222(4-(2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043235(2-(1-Mercapto-ethyl)-4-methyl-pentanoic acid [2-(4...)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043242(3-Acetylsulfanyl-4-[2-(1H-indol-3-yl)-1-methylcarb...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043231(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenase without beta-mercaptoethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043223(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043238(2-Isobutyl-3-mercapto-pentanedioic acid 5-amide 1-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043230(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043229(CHEMBL130164 | {3-Mercapto-4-[2-(4-methoxy-phenyl)...)
Affinity DataIC50:  27nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043243(2-Isobutyl-3-mercapto-pentanedioic acid 5-carbamoy...)
Affinity DataIC50:  32nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043232(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  34nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043220(3-Acetylsulfanyl-4-[2-(4-methoxy-phenyl)-1-methylc...)
Affinity DataIC50:  44nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043224(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  68nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenase without beta-mercaptoethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043225(2-Isobutyl-3-mercapto-5-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043234(2-Isobutyl-3-mercapto-pentanedioic acid 1-{[2-(4-m...)
Affinity DataIC50:  145nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043233(4-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-3-mercapto...)
Affinity DataIC50:  190nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043233(4-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-3-mercapto...)
Affinity DataIC50:  190nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043240(CHEMBL128406 | {3-Mercapto-4-[2-(4-methoxy-phenyl)...)
Affinity DataIC50:  280nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043226(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  730nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043226(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  730nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043236(2-{3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarb...)
Affinity DataIC50:  830nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043239(2-{3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarb...)
Affinity DataIC50:  980nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043241(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  980nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043241(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  980nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043223(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenase without beta-mercaptoethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed