Compile Data Set for Download or QSAR
maximum 50k data
Found 70 Enz. Inhib. hit(s) with all data for entry = 50006429
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049038(5-(4-Chloro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049011(4-[6-(3,4-Dichloro-phenyl)-spiro[2.4]hept-5-en-5-y...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049042(4-[6-(4-Trifluoromethyl-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049025(4-[6-(4-Methoxy-phenyl)-spiro[2.4]hept-5-en-5-yl]-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049014(4-[6-(4-Chloro-phenyl)-spiro[2.4]hept-5-en-5-yl]-b...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049033(4-[6-(3-Chloro-4-fluoro-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049030(5-(4-Methanesulfonyl-phenyl)-6-p-tolyl-spiro[2.4]h...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049037(5-(4-Methanesulfonyl-phenyl)-6-(4-trifluoromethyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049029(4-[6-(3-Chloro-4-methoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049023(4-[6-(3-Fluoro-4-methoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049040(4-[6-(3-Bromo-4-methoxy-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049028(5-[6-(4-Methanesulfonyl-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50029614((SC-57666)1-[2-(4-fluorophenyl)-1-cyclopentenyl]-4...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049010(4-[6-(3,4-Difluoro-phenyl)-spiro[2.4]hept-5-en-5-y...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049024(4-[6-(4-Fluoro-phenyl)-spiro[2.4]hept-5-en-5-yl]-b...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049018(5-(3,4-Dichloro-phenyl)-6-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049013(5-(3,4-Difluoro-phenyl)-6-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049022(6-(4-Fluoro-phenyl)-7-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049027(4-[6-(3,5-Dichloro-4-methoxy-phenyl)-spiro[2.4]hep...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049034(5-(4-Methanesulfonyl-phenyl)-6-(4-methoxy-phenyl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049025(4-[6-(4-Methoxy-phenyl)-spiro[2.4]hept-5-en-5-yl]-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049031(5-(3,5-Dichloro-4-methoxy-phenyl)-6-(4-methanesulf...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049021(5-(3-Chloro-4-fluoro-phenyl)-6-(4-methanesulfonyl-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049041(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049035(5-(3-Fluoro-4-methoxy-phenyl)-6-(4-methanesulfonyl...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049032(5-(3-Bromo-4-methoxy-phenyl)-6-(4-methanesulfonyl-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049019(5-(3-Chloro-4-methoxy-phenyl)-6-(4-methanesulfonyl...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049017(5-(2,4-Difluoro-phenyl)-6-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049036(5-(3-Chloro-4-methoxy-phenyl)-6-(4-methanesulfonyl...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049020(5-(2,4-Dichloro-phenyl)-6-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049039(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  62nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049016(4-[6-(4-Trifluoromethoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049015(5-(4-Methanesulfonyl-phenyl)-6-(4-trifluoromethoxy...)
Affinity DataIC50:  135nMAssay Description:Inhibitory activity of the compound against prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049014(4-[6-(4-Chloro-phenyl)-spiro[2.4]hept-5-en-5-yl]-b...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049033(4-[6-(3-Chloro-4-fluoro-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  310nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049011(4-[6-(3,4-Dichloro-phenyl)-spiro[2.4]hept-5-en-5-y...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049040(4-[6-(3-Bromo-4-methoxy-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049023(4-[6-(3-Fluoro-4-methoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  480nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049042(4-[6-(4-Trifluoromethyl-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049034(5-(4-Methanesulfonyl-phenyl)-6-(4-methoxy-phenyl)-...)
Affinity DataIC50:  570nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049017(5-(2,4-Difluoro-phenyl)-6-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  740nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049010(4-[6-(3,4-Difluoro-phenyl)-spiro[2.4]hept-5-en-5-y...)
Affinity DataIC50:  920nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049026(5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049028(5-[6-(4-Methanesulfonyl-phenyl)-spiro[2.4]hept-5-e...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049016(4-[6-(4-Trifluoromethoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049029(4-[6-(3-Chloro-4-methoxy-phenyl)-spiro[2.4]hept-5-...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049038(5-(4-Chloro-phenyl)-6-(4-methanesulfonyl-phenyl)-s...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049036(5-(3-Chloro-4-methoxy-phenyl)-6-(4-methanesulfonyl...)
Affinity DataIC50:  3.38E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049030(5-(4-Methanesulfonyl-phenyl)-6-p-tolyl-spiro[2.4]h...)
Affinity DataIC50:  4.04E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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