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Found 89 Enz. Inhib. hit(s) with all data for entry = 50006589
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051308((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051302((3-Chloro-phenyl)-(5-methyl-6-phenyl-7H-pyrrolo[2,...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051312((3-Bromo-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051297((3-Chloro-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50:  46nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051305((3-Chloro-phenyl)-(5,6-diphenyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  96nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051320((6,7,8,9-Tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051308((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...)
Affinity DataIC50:  120nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051297((3-Chloro-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataIC50:  120nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051311((3,5-Dichloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051333(3-(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051309((3-Chloro-phenyl)-(6-methyl-5-phenyl-7H-pyrrolo[2,...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040929(4,5-dianilinophthalimide | 5,6-bis(phenylamino)-1H...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051310(CHEMBL433305 | Phenyl-(6,7,8,9-tetrahydro-5H-pyrim...)
Affinity DataIC50:  310nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051321((6,7,8,9-Tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-...)
Affinity DataIC50:  360nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50:  400nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051303(3-(6,7,8,9-Tetrahydro-5H-pyrimido[4,5-b]indol-4-yl...)
Affinity DataIC50:  420nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051318((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051307((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(3-...)
Affinity DataIC50:  550nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051316((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(4-...)
Affinity DataIC50:  560nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051304((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-m-t...)
Affinity DataIC50:  570nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051300((6,7,8,9-Tetrahydro-5H-pyrimido[4,5-b]indol-4-yl)-...)
Affinity DataIC50:  820nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051328((3-Methoxy-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido...)
Affinity DataIC50:  860nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051323(Benzyl-(5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-...)
Affinity DataIC50:  1.08E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051325((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(3-...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051322(3-(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)
Affinity DataIC50:  1.25E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051312((3-Bromo-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051330((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(3-...)
Affinity DataIC50:  1.90E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051319((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phe...)
Affinity DataIC50:  1.90E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051319((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phe...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051332((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-p-t...)
Affinity DataIC50:  2.10E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051312((3-Bromo-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051329(4-(3-Chloro-phenoxy)-5,6-dimethyl-7H-pyrrolo[2,3-d...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051305((3-Chloro-phenyl)-(5,6-diphenyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051310(CHEMBL433305 | Phenyl-(6,7,8,9-tetrahydro-5H-pyrim...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051304((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-m-t...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051302((3-Chloro-phenyl)-(5-methyl-6-phenyl-7H-pyrrolo[2,...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051309((3-Chloro-phenyl)-(6-methyl-5-phenyl-7H-pyrrolo[2,...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051326(CHEMBL419635 | Cyclohexyl-(2,5,6-trimethyl-7H-pyrr...)
Affinity DataIC50:  6.92E+3nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051327(3-(5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...)
Affinity DataIC50:  1.63E+4nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051331(3-(6,7,8,9-Tetrahydro-5H-pyrimido[4,5-b]indol-4-yl...)
Affinity DataIC50:  2.57E+4nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051308((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1/ABL2(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  4.05E+4nMAssay Description:Inhibition of tyrosine kinase v-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051324((4-Ethyl-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051315((4-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Ciba Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051319((5,6-Dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-phe...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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