Compile Data Set for Download or QSAR
maximum 50k data
Found 42 Enz. Inhib. hit(s) with all data for entry = 50006679
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052343(3-Biphenyl-4-ylethynyl-1-aza-bicyclo[2.2.2]octan-3...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052350(3-((E)-2-Biphenyl-4-yl-vinyl)-1-aza-bicyclo[2.2.2]...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052342(3-(2-Biphenyl-4-yl-ethyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052353(3-(4-Benzothiazol-2-yl-phenyl)-1-aza-bicyclo[2.2.2...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052355(3-(2-Biphenyl-4-yl-ethyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052377(3-(Biphenyl-4-ylsulfanylmethyl)-1-aza-bicyclo[2.2....)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052376(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octane | CHEMB...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052358(3-(Biphenyl-4-yloxymethyl)-1-aza-bicyclo[2.2.2]oct...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052351(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052366(3-(4'-Fluoro-biphenyl-4-yl)-1-aza-bicyclo[2.2.2]oc...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052352(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052367(3-(Biphenyl-4-ylsulfanyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052357(3-Biphenyl-4-ylmethyl-1-aza-bicyclo[2.2.2]octane |...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052372(3-(4-Thiazol-2-yl-phenyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052341(3-(4-Pyrimidin-2-yl-phenyl)-1-aza-bicyclo[2.2.2]oc...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052364(3-(4-Thiophen-2-yl-phenyl)-1-aza-bicyclo[2.2.2]oct...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052373(3-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylo...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052344(3-Biphenyl-3-yl-1-aza-bicyclo[2.2.2]octan-3-ol | C...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052362(3-(2-Phenyl-thiazol-5-yl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052361(3-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylo...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052351(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...)
Affinity DataIC50:  121nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052359(3-(4'-Hydroxy-biphenyl-4-yl)-1-aza-bicyclo[2.2.2]o...)
Affinity DataIC50:  132nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052354((1-Aza-bicyclo[2.2.2]oct-3-yl)-biphenyl-4-ylmethyl...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052345(3-(4-Pyridin-4-yl-phenyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  161nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052356(3-(4-Cyclohexyl-phenyl)-1-aza-bicyclo[2.2.2]octan-...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052360(3-(4-Quinolin-3-yl-phenyl)-1-aza-bicyclo[2.2.2]oct...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052378(3-(4-Pyridin-2-yl-phenyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  240nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052374(3-(4-Pyridin-3-yl-phenyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052349(3-[1,1';4',1'']Terphenyl-4-yl-1-aza-bicyclo[2.2.2]...)
Affinity DataIC50:  370nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052346(3-((Z)-2-Biphenyl-4-yl-vinyl)-1-aza-bicyclo[2.2.2]...)
Affinity DataIC50:  580nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052371(Biphenyl-4-carboxylic acid (1-aza-bicyclo[2.2.2]oc...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052369((1-Aza-bicyclo[2.2.2]oct-3-yl)-biphenyl-4-yl-metha...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052375(3-(Biphenyl-4-sulfonylmethyl)-1-aza-bicyclo[2.2.2]...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052340(3-(4-[1,3]Dioxan-2-yl-phenyl)-1-aza-bicyclo[2.2.2]...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052370(3-(Biphenyl-4-sulfonyl)-1-aza-bicyclo[2.2.2]octane...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052365(3-Biphenyl-4-yl-3-methoxy-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052347(3-(Biphenyl-4-sulfinylmethyl)-1-aza-bicyclo[2.2.2]...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052348(Biphenyl-4-sulfonic acid (1-aza-bicyclo[2.2.2]oct-...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052363(3-Phenyl-1-aza-bicyclo[2.2.2]octan-3-ol | CHEMBL10...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052368(3-[2,2']Bithiophenyl-5-yl-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052369((1-Aza-bicyclo[2.2.2]oct-3-yl)-biphenyl-4-yl-metha...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029160(CHEMBL55300 | Disodium salt of 13-[-2,6,10-trimeth...)
Affinity DataIC50:  3.00E+4nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed