Compile Data Set for Download or QSAR
maximum 50k data
Found 18 Enz. Inhib. hit(s) with all data for entry = 50007597
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065136(CHEMBL81455 | N-(2-Azepan-1-yl-ethyl)-4-iodo-N-met...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065134(CHEMBL309983 | N-(2-Azepan-1-yl-ethyl)-4-bromo-N-m...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065140(4-Iodo-N-(2-piperidin-1-yl-ethyl)-benzenesulfonami...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065144(CHEMBL79660 | N-(2-Azepan-1-yl-ethyl)-4-bromo-benz...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  0.700nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065142(CHEMBL439765 | N-(2-Azepan-1-yl-ethyl)-4-iodo-benz...)
Affinity DataKi:  1.32nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065135(4-Iodo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  1.46nMAssay Description:Inhibition Constant for 4-[125I]-IPBS binding to sigma 1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065141(4-Bromo-N-(2-piperidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  1.54nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065143(CHEMBL83448 | N-(2-Azepan-1-yl-ethyl)-3-iodo-4-met...)
Affinity DataKi:  3.11nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.70nMAssay Description:Compound was evaluated for its invitro competition binding studies using sigma-ligand (0.05-10000 nM) - [3H]-(+)-pentazocine (sigma1 receptor) in gui...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065135(4-Iodo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfonam...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065138(CHEMBL81451 | N-(2-Diethylamino-ethyl)-4-iodo-benz...)
Affinity DataKi:  4.97nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065133(4-Bromo-N-(2-pyrrolidin-1-yl-ethyl)-benzenesulfona...)
Affinity DataKi:  6.65nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065139(4-Bromo-N-(2-diethylamino-ethyl)-benzenesulfonamid...)
Affinity DataKi:  10.1nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50010774(CHEMBL539782 | CHEMBL83430 | N,N'-Dibenzyl-guanidi...)
Affinity DataKi:  27.7nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065145(3-Iodo-4-methoxy-N-(2-piperidin-1-yl-ethyl)-benzen...)
Affinity DataKi:  41.8nMAssay Description:Inhibition of [3H]-(+)-pentazocine binding to sigma-1 receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The George Washington University Medical Center

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  152nMAssay Description:Compound was evaluated for its inhibition constant from the competition binding assays for sigma-1 receptor in guinea pig membranes.More data for this Ligand-Target Pair