Compile Data Set for Download or QSAR
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Found 16 Enz. Inhib. hit(s) with all data for entry = 50008233
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071695((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity was evaluated against thrombin (FIIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071695((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity was evaluated against human trypsin cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071694(2-((R)-3-Amino-3-benzyl-2-oxo-piperidin-1-yl)-N-((...)
Affinity DataIC50:  2.10nMAssay Description:In vitro inhibitory activity was evaluated against thrombin (FIIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071695((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50:  5.80nMAssay Description:In vitro inhibitory activity was evaluated against thrombin factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071693(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)
Affinity DataIC50:  6.20nMAssay Description:In vitro inhibitory activity was evaluated against thrombin (FIIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071696((S)-1-[((2S,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibitory activity was evaluated against thrombin factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071696((S)-1-[((2S,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50:  64nMAssay Description:In vitro inhibitory activity was evaluated against thrombin (FIIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071697(2-((R)-3-Amino-3-benzyl-2-oxo-piperidin-1-yl)-N-((...)
Affinity DataIC50:  138nMAssay Description:In vitro inhibitory activity was evaluated against thrombin (FIIa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071694(2-((R)-3-Amino-3-benzyl-2-oxo-piperidin-1-yl)-N-((...)
Affinity DataIC50:  139nMAssay Description:In vitro inhibitory activity was evaluated against human trypsin cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071696((S)-1-[((2S,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50:  202nMAssay Description:In vitro inhibitory activity was evaluated against human trypsin cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071695((S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50:  271nMAssay Description:In vitro inhibitory activity was evaluated against thrombolytic enzyme plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071693(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)
Affinity DataIC50:  791nMAssay Description:In vitro inhibitory activity was evaluated against human trypsin cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071697(2-((R)-3-Amino-3-benzyl-2-oxo-piperidin-1-yl)-N-((...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibitory activity was evaluated against human trypsin cleavage of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071693(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibitory activity was evaluated against thrombin factor Xa (FXa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071693(CHEMBL38927 | CVS-1578 | N-((S)-1-Carbamimidoyl-2-...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibitory activity was evaluated against thrombolytic enzyme plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Corvas International

Curated by ChEMBL
LigandPNGBDBM50071696((S)-1-[((2S,3S)-1-Carbamimidoyl-2-hydroxy-piperidi...)
Affinity DataIC50: >2.50E+3nMAssay Description:In vitro inhibitory activity was evaluated against thrombolytic enzyme plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed