Compile Data Set for Download or QSAR
maximum 50k data
Found 41 Enz. Inhib. hit(s) with all data for entry = 50034965
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072257(2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  180nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072257(2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  180nMAssay Description:Compound was evaluated for inhibition of human recombinant KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50061915(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)
Affinity DataIC50:  200nMAssay Description:Compound was evaluated for inhibition of human recombinant KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50061915(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)
Affinity DataIC50:  200nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072242(4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyric ac...)
Affinity DataIC50:  300nMAssay Description:Compound was evaluated for inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50061915(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)
Affinity DataIC50:  330nMAssay Description:Compound was evaluated for the inhibition of rat liver KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072248((S)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyri...)
Affinity DataIC50:  420nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072244((Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  440nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072249(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-butyric acid |...)
Affinity DataIC50:  480nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072245(4-(3,4-Dichloro-phenyl)-4-oxo-butyric acid | CHEMB...)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072254((E)-4-(3,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid...)
Affinity DataIC50:  900nMAssay Description:Compound was evaluated for inhibition of rat brain KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072260((Z)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  950nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072255((E)-4-(3,4-Difluoro-phenyl)-4-oxo-but-2-enoic acid...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072249(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-butyric acid |...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072244((Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072250(4-(3,4-Dichloro-phenyl)-2-methoxy-4-oxo-butyric ac...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072242(4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyric ac...)
Affinity DataIC50:  1.40E+3nMAssay Description:Compound was evaluated for inhibition of rat liver KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072252(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-butyric ac...)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072258(2-Hydroxy-4-(3-nitro-phenyl)-4-oxo-butyric acid | ...)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072251(2-Chloro-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072253(4-(3,4-Dichloro-phenyl)-2-methylene-4-oxo-butyric ...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072259((S)-2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072257(2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072252(4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-butyric ac...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072242(4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyric ac...)
Affinity DataIC50:  3.30E+3nMAssay Description:Compound was evaluated for inhibition of human recombinant KYN 3-OHaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072247(4-(3,4-Dichloro-phenyl)-2-methyl-4-oxo-butyric aci...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072245(4-(3,4-Dichloro-phenyl)-4-oxo-butyric acid | CHEMB...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072246(4-(3-Fluoro-phenyl)-2-hydroxy-4-oxo-butyric acid |...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072260((Z)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-but-2-...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072247(4-(3,4-Dichloro-phenyl)-2-methyl-4-oxo-butyric aci...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072250(4-(3,4-Dichloro-phenyl)-2-methoxy-4-oxo-butyric ac...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072246(4-(3-Fluoro-phenyl)-2-hydroxy-4-oxo-butyric acid |...)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of rat brain KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072254((E)-4-(3,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072262((R)-2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072253(4-(3,4-Dichloro-phenyl)-2-methylene-4-oxo-butyric ...)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072258(2-Hydroxy-4-(3-nitro-phenyl)-4-oxo-butyric acid | ...)
Affinity DataIC50:  1.15E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072261((R)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyri...)
Affinity DataIC50:  1.44E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072251(2-Chloro-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072243(4-(3,4-Dichloro-phenyl)-4-oxo-2-phenyl-butyric aci...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072255((E)-4-(3,4-Difluoro-phenyl)-4-oxo-but-2-enoic acid...)
Affinity DataIC50:  2.11E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50072253(4-(3,4-Dichloro-phenyl)-2-methylene-4-oxo-butyric ...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of rat liver KYN 3-OHase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed