Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 706
TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287942BDBM287942(N-(4-(4-((2-phenyl-2-(pyridin-4- yl)ethyl)amino)qu...)
Affinity DataEC50:  4.80nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287946BDBM287946(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(1H-pyr...)
Affinity DataEC50:  5.60nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287937BDBM287937(2-((2-(4- (dimethylamino)phenyl)quinazolin-4- yl)a...)
Affinity DataEC50:  6.70nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287961BDBM287961(N-(3-methyl-4-(4-((2-phenyl-2- (pyridin-4-yl)ethyl...)
Affinity DataEC50:  7.40nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287936BDBM287936(N-(4-(4-((2-hydroxy-2,2- diphenylethyl)amino)quina...)
Affinity DataEC50:  11nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287943BDBM287943(2-(4-dimethylamino)phenyl)-N-(2- phenyl-2-(pyridin...)
Affinity DataEC50:  13nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287971BDBM287971(2-(4-(dimethylamino)phenyl)-N-(2,2- diphenylpropyl...)
Affinity DataEC50:  15nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287950BDBM287950(2-(4-(dimethylamino)phenyl)-N-(2- morpholino-2-phe...)
Affinity DataEC50:  15nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287938BDBM287938(N-(4-(4-((2-cyclohexyl-2- phenylethyl)amino)quinaz...)
Affinity DataEC50:  16nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287972BDBM287972(N-(4-(4-((2,2- diphenylpropyl)amino)quinazolin-2- ...)
Affinity DataEC50:  16nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287960BDBM287960((5-(2-((2-(4-(dimethylamino)-2- methylphenyl)quina...)
Affinity DataEC50:  18nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287978BDBM287978(N-(4-(4-((3-methyl-2- phenylbutyl)amino)quinazolin...)
Affinity DataEC50:  20nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287967BDBM287967(N-(2,2-di(pyridin-4-yl)ethyl)-2-(4- (dimethylamino...)
Affinity DataEC50:  21nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287935BDBM287935(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyridi...)
Affinity DataEC50:  22nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287956BDBM287956(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyridi...)
Affinity DataEC50:  24nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287957BDBM287957(N-(4-(4-((2-phenyl-2-(pyridin-3- yl)ethyl)amino)qu...)
Affinity DataEC50:  25nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287954BDBM287954(2-(4-(dimethylamino)phenyl)-N-(2-(4- methylpiperaz...)
Affinity DataEC50:  30nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287977BDBM287977(2-(4-(dimethylamino)phenyl)-N-(3- methyl-2-phenylb...)
Affinity DataEC50:  30nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287982BDBM287982(N-(4-(4-((2-phenoxy-2- phenylethyl)amino)quinazoli...)
Affinity DataEC50:  30nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287948BDBM287948(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(piperi...)
Affinity DataEC50:  34nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287958BDBM287958(2-(4-(dimethylamino)phenyl)-N-(2,3- diphenylpropyl...)
Affinity DataEC50:  39nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287973BDBM287973(2-(4-(dimethylamino)phenyl)-N-(1,2- diphenylethyl)...)
Affinity DataEC50:  40nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287981BDBM287981(2-(4-(dimethylamino)phenyl)-N-(2- phenoxy-2-phenyl...)
Affinity DataEC50:  42nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287951BDBM287951(N-(4-(4-((2-morpholino-2- phenylethyl)amino)quinaz...)
Affinity DataEC50:  43nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287947BDBM287947(N-(4-(4-((2-phenyl-2-(1H-pyrrol-2- yl)ethyl)amino)...)
Affinity DataEC50:  43nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287939BDBM287939(N-(2-cyclohexyl-2-phenylethyl)-2-(4- (dimethylamin...)
Affinity DataEC50:  46nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287968BDBM287968(N-(4-(4-((2,2-di(pyridin-4- yl)ethyl)amino)quinazo...)
Affinity DataEC50:  47nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287964BDBM287964(2-(4-(dimethylamino)phenyl)-N-(2- (pyridin-3-yl)-2...)
Affinity DataEC50:  47nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287974BDBM287974(N-(4-(4-((1,2- diphenylethyl)amino)quinazolin-2- y...)
Affinity DataEC50:  50nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287934BDBM287934(N-(4-(4-((2-phenyl-2-(pyridin-2- yl)ethyl)amino)qu...)
Affinity DataEC50:  50nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287959BDBM287959(N-(4-(4-((2,3- diphenylpropyl)amino)quinazolin-2- ...)
Affinity DataEC50:  58nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287955BDBM287955(N-(4-(4-((2-(4-methylpiperazin-1-yl)-2- phenylethy...)
Affinity DataEC50:  62nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287949BDBM287949(N-(4-(4-((2-phenyl-2-(piperidin-1- yl)ethyl)amino)...)
Affinity DataEC50:  62nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287966BDBM287966(2-(4-(dimethylamino)phenyl)-N-(2- (pyridin-2-yl)-2...)
Affinity DataEC50:  65nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287975BDBM287975(N-(4-(4-((1,3- diphenylpropyl)amino)quinazolin-2- ...)
Affinity DataEC50:  71nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287976BDBM287976(2-(4-(dimethylamino)phenyl)-N-(1,3- diphenylpropyl...)
Affinity DataEC50:  75nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287980BDBM287980(N-(4-(4-((2,2-di(pyridin-4- yl)ethyl)amino)quinazo...)
Affinity DataEC50:  84nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287944BDBM287944(N-(4-(4-((2-(1H-imidazol-1-yl)-2- phenylethyl)amin...)
Affinity DataEC50:  100nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287953BDBM287953(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyrrol...)
Affinity DataEC50:  112nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287941BDBM287941(2-(4-(dimethylamino)phenyl)-N-(2- phenyl-2-(pyrimi...)
Affinity DataEC50:  117nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287945BDBM287945(N-(2-(1H-imidazol-1-yl)-2- phenylethyl)-2-(4- (dim...)
Affinity DataEC50:  138nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287969BDBM287969(2-(4-(dimethylamino)phenyl)-N- phenethylquinazolin...)
Affinity DataEC50:  156nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287970BDBM287970(N-(4-(4-(phenethylamino)quinazolin-2- yl)phenyl)me...)
Affinity DataEC50:  159nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287952BDBM287952(N-(4-(4-((2-phenyl-2-(pyrrolidin-1- yl)ethyl)amino...)
Affinity DataEC50:  160nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287962BDBM287962(N-(4-(4-((2-(pyridin-3-yl)-2-(1H- pyrrol-2-yl)ethy...)
Affinity DataEC50:  202nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287979BDBM287979((1R,2S)-2-(((2-(4- (dimethylamino)phenyl)quinazoli...)
Affinity DataEC50:  243nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287965BDBM287965(N-(4-(4-((2-(pyridin-2-yl)-2-(1H- pyrrol-2-yl)ethy...)
Affinity DataEC50:  379nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287933BDBM287933(N-(2-(6-chloropyridin-2-yl)-2- phenylethyl)-2-(p-t...)
Affinity DataEC50:  380nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetSodium-dependent dopamine transporter(Human)
The United States of America As Represented By The Secretary, Department of Health and Human Services Office of Technology Transfer, National Institute of Health

US Patent
LigandChemical structure of BindingDB Monomer ID 287940BDBM287940(N-(4-(4-((2-phenyl-2-(pyrimidin-2- yl)ethyl)amino)...)
Affinity DataEC50:  477nMpH: 7.4Assay Description:Uptake inhibition assay for the dopamine transporter was conducted in rat brain synaptosomes as described elsewhere with minor modifications (Rothman...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent