Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 966
TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300907(US10131651, Example 7 | BDBM300908 | (2S,3R)-3-cyc...)
Affinity DataEC50:  3nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300905(US10131651, Example 5 | (2S,3R)-3-cyclopropyl-3-((...)
Affinity DataEC50:  3.10nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300901((2S,3R)-3-cyclopropyl-3-((R or S)-2-(2-fluoro-4-(2...)
Affinity DataEC50:  3.60nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300910(US10131651, Example 10 | BDBM300911)
Affinity DataEC50:  4.60nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300905(US10131651, Example 5 | (2S,3R)-3-cyclopropyl-3-((...)
Affinity DataEC50:  5.20nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300910(US10131651, Example 10 | BDBM300911)
Affinity DataEC50:  6nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300903((2S, 3R)-3-((R or S)-2-(1-(2, 5-bis (trifluorometh...)
Affinity DataEC50:  13nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300901((2S,3R)-3-cyclopropyl-3-((R or S)-2-(2-fluoro-4-(2...)
Affinity DataEC50:  14nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300904((2S,3R)-3-((R or S)-2-(1- (2,5-bis(trifluoromethyl...)
Affinity DataEC50:  27nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300907(US10131651, Example 7 | BDBM300908 | (2S,3R)-3-cyc...)
Affinity DataEC50:  29nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300912(US10131651, Example 12)
Affinity DataEC50:  116nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300913(US10131651, Example 13)
Affinity DataEC50:  684nMAssay Description:The assay is performed in 384-well format. HEK cells stably expressing human GPR40 are plated at 15,000 cells per well in growth medium (DMEM/10% fet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetFree fatty acid receptor 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM300909(3-(2-(2′,6′-dimethyl-[1,1′-biphe...)
Affinity DataEC50:  3.30E+3nMAssay Description:FLIPR (Fluorimetric Imaging Plate Reader, Molecular Devices) assays were performed to measure agonist-induced calcium mobilization of the stable clon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent