Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 1579
TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331838((R)-7-[4-(2-ethoxycarbonyl-2-hydroxyethyl)oxy-2-me...)
Affinity DataIC50: 1nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331841((S)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50: 13nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331840((R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...)
Affinity DataIC50: 14nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331839((S)-7-[4-(2,4-dihydroxybutyl)oxy-2-methoxyphenyl]-...)
Affinity DataIC50: 15nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331836((S)-8-(5-fluoro-2-methylphenoxymethyl)-7-[4-(2-hyd...)
Affinity DataIC50: 33nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331837((R)-8-(5-fluoro-2-methylphenoxymethyl)-7-[4-(2-hyd...)
Affinity DataIC50: 34nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331842(7-[4-(3-t-butoxycarbonyl-2-hydroxypropyl)oxy-2-met...)
Affinity DataIC50: 83nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331844(8-(5-fluoro-2-methylphenoxymethyl)-7-(5-hydroxy-2-...)
Affinity DataIC50: 93nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331843(8-(5-fluoro-2-methylphenoxymethyl)-7-(5-hydroxymet...)
Affinity DataIC50: 123nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent