Compile Data Set for Download or QSAR
Report error Found 434 Enz. Inhib. hit(s) with all data for entry = 1976
TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349672BDBM349672(2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...)
Affinity DataEC50:  0.280nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349765BDBM349765(US10208019, Example 10A-35 | 2-[(4-{6-[(4-cyano-2-...)
Affinity DataEC50:  0.300nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349740BDBM349740(2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...)
Affinity DataEC50:  0.300nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349777BDBM349777(US10208019, Example 10A-47 | 2-{[(2S)-4-{6-[(4-cya...)
Affinity DataEC50:  0.300nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349766BDBM349766(US10208019, Example 10A-36 | 2-[(4-{6-[(4-chloro-2...)
Affinity DataEC50:  0.330nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349732BDBM349732(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  0.340nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349709BDBM349709(2-[(4-{6-[(4-Cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  0.340nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349796BDBM349796(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  0.390nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349762BDBM349762(US10208019, Example 10A-32 | 2-[(4-{6-[(2,4-difluo...)
Affinity DataEC50:  0.470nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349786BDBM349786(US10208019, Example 10A-56 | 2-{[(2S)-4-{6-[(2,4-d...)
Affinity DataEC50:  0.5nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349706BDBM349706(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  0.5nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349788BDBM349788(US10208019, Example 10A-58 | 2-{[(2S)-4-{6-[(2,4-d...)
Affinity DataEC50:  0.520nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349738BDBM349738(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  0.550nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349779BDBM349779(US10208019, Example 10A-49 | 2-{[(2S)-4-{6-[(4-cya...)
Affinity DataEC50:  0.560nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349793BDBM349793(2-{[(2S)-4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin...)
Affinity DataEC50:  0.580nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349797BDBM349797(2-{[(2S)-4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridi...)
Affinity DataEC50:  0.590nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349879BDBM349879(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  0.700nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349784BDBM349784(US10208019, Example 10A-54 | 2-[(4-{6-[(4-cyano-2-...)
Affinity DataEC50:  0.710nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349710BDBM349710(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  0.760nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349804BDBM349804(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  0.900nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349707BDBM349707(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  0.940nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349662BDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)
Affinity DataEC50:  0.950nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349805BDBM349805(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  0.950nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349703BDBM349703(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  0.960nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349807BDBM349807(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  0.960nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349739BDBM349739(2-{[(2S)-4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin...)
Affinity DataEC50:  0.990nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349775BDBM349775(US10208019, Example 10A-45 | 2-[(4-{6-[(4-chloro-2...)
Affinity DataEC50:  1nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349662BDBM349662(2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy...)
Affinity DataEC50:  1.10nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349785BDBM349785(US10208019, Example 10A-55 | 2-[(4-{6-[(4-cyanoben...)
Affinity DataEC50:  1.20nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349745BDBM349745(US10208019, Example 10A-15 | 2-{[(2S)-4-{6-[(4-cya...)
Affinity DataEC50:  1.30nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349909BDBM349909(2-{[(2S)-4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin...)
Affinity DataEC50:  1.40nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349669BDBM349669(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  1.5nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349764BDBM349764(US10208019, Example 10A-34 | 2-[(4-{6-[(4-cyano-2-...)
Affinity DataEC50:  1.5nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349763BDBM349763(US10208019, Example 10A-33 | 2-[(4-{6-[(4-chloro-2...)
Affinity DataEC50:  1.5nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349791BDBM349791(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  1.5nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349748BDBM349748(US10208019, Example 10A-18 | 2-{[(2S)-4-{6-[(4-chl...)
Affinity DataEC50:  1.60nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349795BDBM349795(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  1.60nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349808BDBM349808(2-[(4-{6-[(4-cyanobenzyl)oxy]pyridin-2-yl}piperidi...)
Affinity DataEC50:  1.60nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349746BDBM349746(US10208019, Example 10A-16 | 2-{[(2S)-4-{6-[(4-chl...)
Affinity DataEC50:  1.70nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349755BDBM349755(US10208019, Example 10A-25 | 2-{[(2S)-4-{6-[(4-cya...)
Affinity DataEC50:  1.70nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349747BDBM349747(US10208019, Example 10A-17 | 2-{[(2S)-4-{6-[(4-cya...)
Affinity DataEC50:  1.80nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349905BDBM349905(2-{[(2S)-4-{6-[(4-cyanobenzyl)oxy]pyridin-2-yl}-2-...)
Affinity DataEC50:  1.90nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349794BDBM349794(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  2nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349799BDBM349799(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  2nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349732BDBM349732(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  2.20nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349670BDBM349670(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  2.40nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349735BDBM349735(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  2.40nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349772BDBM349772(US10208019, Example 10A-42 | 2-[(4-{6-[(4-chloro-2...)
Affinity DataEC50:  2.70nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349737BDBM349737(2-[(4-{6-[(4-chloro-2-fluorobenzyl)oxy]pyridin-2-y...)
Affinity DataEC50:  2.80nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetGlucagon-like peptide 1 receptor(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 349806BDBM349806(2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl...)
Affinity DataEC50:  2.90nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

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