Compile Data Set for Download or QSAR
Report error Found 266 Enz. Inhib. hit(s) with all data for entry = 2952
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386188BDBM386188((2R,3S)-N-ethyl-2-(((cis-4-(3- fluorophenyl)cycloh...)
Affinity DataEC50:  0.0530nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386088BDBM386088((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.110nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386162BDBM386162(cis-N-ethyl-2-(((cis-4-(2- fluorophenyl)cyclohexyl...)
Affinity DataEC50:  0.120nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386174BDBM386174(cis-2-(((cis-4-(2,3- difluorophenyl)cyclohexyl)oxy...)
Affinity DataEC50:  0.220nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386205BDBM386205(cis-N-(cyanomethyl)-3- ((methylsulfonyl)amino)-2-(...)
Affinity DataEC50:  0.310nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386900BDBM386900(cis-3-((cyclopropylsulfonyl)amino)- N-ethyl-2-(((c...)
Affinity DataEC50:  0.440nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386252BDBM386252(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2,...)
Affinity DataEC50:  0.440nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386842BDBM386842((2R,3S)-N-ethyl-3- ((methylsulfonyl)amino)-2-(((ci...)
Affinity DataEC50:  0.550nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386816BDBM386816(cis-N-ethyl-3- ((methylsulfonyl)amino)-2-(((cis-4-...)
Affinity DataEC50:  0.610nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386089BDBM386089(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4- ph...)
Affinity DataEC50:  0.660nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386823BDBM386823(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2,...)
Affinity DataEC50:  0.720nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386075BDBM386075(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(3-...)
Affinity DataEC50:  0.840nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386810BDBM386810(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(3,...)
Affinity DataEC50:  0.880nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386184BDBM386184(cis-2-(((cis-4-(3,4- difluorophenyl)cyclohexyl)oxy...)
Affinity DataEC50:  1nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386903BDBM386903(cis-3-((cyclopropylsulfonyl)amino)- N-methyl-2-(((...)
Affinity DataEC50:  1.10nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386149BDBM386149((2R,3S)-2-(((cis-4- isopropylcyclohexyl)oxy)methyl...)
Affinity DataEC50:  1.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386809BDBM386809(methyl (2R,3S)-2-(((cis-4-(3,5- difluorophenyl)cyc...)
Affinity DataEC50:  1.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386831BDBM386831(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2-...)
Affinity DataEC50:  1.5nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386256BDBM386256(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2,...)
Affinity DataEC50:  1.5nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386817BDBM386817(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2,...)
Affinity DataEC50:  1.70nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386064BDBM386064(US10287305, Example 104 | (2R,3S)-N-ethyl-2-(((cis...)
Affinity DataEC50:  1.90nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386071BDBM386071(methyl (2R,3S)-2-(((cis-4-(2,5- difluorophenyl)cyc...)
Affinity DataEC50:  2nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386813BDBM386813(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2,...)
Affinity DataEC50:  2nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386864BDBM386864(N'-((2R,3S)-1- (cyclopropylcarbonyl)-2-(((cis-4- p...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386067BDBM386067(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386147BDBM386147(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-3-...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386225BDBM386225(methyl (2R,3S)-2-(((cis-4-(3- fluorophenyl)cyclohe...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386064BDBM386064(US10287305, Example 104 | (2R,3S)-N-ethyl-2-(((cis...)
Affinity DataEC50:  2.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386148BDBM386148(cis-N-isopropyl-2-(((cis-4- isopropylcyclohexyl)ox...)
Affinity DataEC50:  2.30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386208BDBM386208(N-((2R,3S)-2-(((cis-4- phenylcyclohexyl)oxy)methyl...)
Affinity DataEC50:  2.30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386186BDBM386186(cis-2-(((cis-4-(2,4- difluorophenyl)cyclohexyl)oxy...)
Affinity DataEC50:  2.5nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386257BDBM386257(methyl (2R,3S)-2-(((cis-4-(2,6- difluorophenyl)cyc...)
Affinity DataEC50:  2.5nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386889BDBM386889(N-((2R,3S)-1-glycoloyl-2-(((cis-4- (2,3,6- trifluo...)
Affinity DataEC50:  2.5nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386822BDBM386822(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.60nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386812BDBM386812(methyl (2R,3S)-3- ((methylsulfonyl)amino)-2-(((cis...)
Affinity DataEC50:  2.60nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386086BDBM386086(N-((2R,3S)-1-(cyclopropylcarbonyl)- 2-(((cis-4-(2-...)
Affinity DataEC50:  2.70nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386145BDBM386145(cis-2-(((cis-4- isopropylcyclohexyl)oxy)methyl)-3-...)
Affinity DataEC50:  2.90nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386216BDBM386216(methyl-d3 (2R,3S)-3- ((methylsulfonyl)amino)-2-(((...)
Affinity DataEC50:  2.90nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386839BDBM386839(methyl (2R,3S)-2-(((cis-4-(2- methoxyphenyl)cycloh...)
Affinity DataEC50:  2.90nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386863BDBM386863(methyl (2R,3S)-3- ((dimethylsulfamoyl)amino)-2- ((...)
Affinity DataEC50:  3.10nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386078BDBM386078(methyl (2R,3S)-2-(((cis-4-(2,3- difluorophenyl)cyc...)
Affinity DataEC50:  3.40nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386830BDBM386830(methyl (2R,3S)-2-(((cis-4-(2- fluorophenyl)cyclohe...)
Affinity DataEC50:  3.40nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386851BDBM386851(cis-N-ethyl-3- ((methylsulfonyl)amino)-2-(((cis-4-...)
Affinity DataEC50:  4.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386143BDBM386143(cis-N-(2-hydroxyethyl)-2-(((cis-4- isopropylcycloh...)
Affinity DataEC50:  4.5nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386163BDBM386163(cis-N-ethyl-3-((methylsulfonyl)amino)- 2-(((1-(pyr...)
Affinity DataEC50:  4.60nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386840BDBM386840(N-(cis-1-(cyclopropylcarbonyl)-2- (((cis-4- phenyl...)
Affinity DataEC50:  5.20nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386080BDBM386080(N-((2R,3S)-1-acetyl-2-(((cis-4- (2,3,6- trifluorop...)
Affinity DataEC50:  5.30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386069BDBM386069(N-((2R,3S)-1-acetyl-2-(((cis-4- (3,5- difluorophen...)
Affinity DataEC50:  5.60nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386885BDBM386885(methyl cis-2-(((cis-4-(2- chlorophenyl)cyclohexyl)...)
Affinity DataEC50:  6.10nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 386073BDBM386073(N-((2R, 3S)-1-acetyl-2-(((cis-4- (2,6- difluorophe...)
Affinity DataEC50:  6.60nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

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