Compile Data Set for Download or QSAR
Report error Found 67 Enz. Inhib. hit(s) with all data for entry = 8752
TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416667BDBM416667(US10323028, Example 11(b) | (2R)-2-Methoxy-2-[3-me...)
Affinity DataIC50: 6.11nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416666BDBM416666(US10323028, Example 11(a) | (2S)-2-Methoxy-2-[3-me...)
Affinity DataIC50: 6.35nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416690BDBM416690(US10323028, Example 23 | US10323028, Example 43 | ...)
Affinity DataIC50: 20nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416686BDBM416686(US10323028, Example 21(a) | (2S)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 20nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416638BDBM416638(US10323028, Example 1(a) | (2S)-2-[3-(3-Fluoroazet...)
Affinity DataIC50: 20.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416680BDBM416680(US10323028, Example 18(a) | (2S)-2-Methoxy-2-[3-(o...)
Affinity DataIC50: 22.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416693BDBM416693(US10323028, Example 26 | 2-(3,5-dimethoxyphenyl)-N...)
Affinity DataIC50: 23.5nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416676BDBM416676(US10323028, Example 16(a) | (2S)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 25.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416654BDBM416654(US10323028, Example 6(a) | (2S)-2-(3,5-Dimethoxyph...)
Affinity DataIC50: 28nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416652BDBM416652(US10323028, Example 5(a) | (2R)-3-Methoxy-2-(3-met...)
Affinity DataIC50: 28.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416643BDBM416643(US10323028, Example 3(a) | (2S)-2-Methoxy-2-[3-(3-...)
Affinity DataIC50: 30.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416664BDBM416664(US10323028, Example 10(a) | (2S)-2-[3-(3-Fluoroaze...)
Affinity DataIC50: 34.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416682BDBM416682(US10323028, Example 19(a) | (2S)-2-Ethoxy-N-[5-[[(...)
Affinity DataIC50: 40.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416650BDBM416650(US10323028, Example 4(a) | (2S)-2-(3,5-Dimethoxyph...)
Affinity DataIC50: 42.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416668BDBM416668(US10323028, Example 12(a) | (2S)-2-Methoxy-2-[3-(3...)
Affinity DataIC50: 43.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416708BDBM416708(US10323028, Example 41 | 2-[3-(3,3-difluoroazetidi...)
Affinity DataIC50: 46.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416690BDBM416690(US10323028, Example 23 | US10323028, Example 43 | ...)
Affinity DataIC50: 48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416690BDBM416690(US10323028, Example 23 | US10323028, Example 43 | ...)
Affinity DataIC50: 48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416687BDBM416687(US10323028, Example 21(b) | (2R)-2-(3,5-Dimethoxyp...)
Affinity DataIC50: 48.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416678BDBM416678(US10323028, Example 17(a) | (2S)-[3-(Difluorometho...)
Affinity DataIC50: 50.4nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416696BDBM416696(US10323028, Example 29 | 2-[3-(3,3-difluoroazetidi...)
Affinity DataIC50: 51.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416691BDBM416691(US10323028, Example 24 | US10323028, Example 25 | ...)
Affinity DataIC50: 52.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416661BDBM416661(US10323028, Example 9(a) | (2S)-N-[5-[[(3R)-1-(6-F...)
Affinity DataIC50: 59.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416651BDBM416651(US10323028, Example 4(b) | (2R)-2-(3,5-Dimethoxyph...)
Affinity DataIC50: 59.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416685BDBM416685(US10323028, Example 20(b) | (2R)-2-[4-Fluoro-3-(tr...)
Affinity DataIC50: 64.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416657BDBM416657(US10323028, Example 8(a) | (2S)-2-[4-Fluoro-3-(3-f...)
Affinity DataIC50: 64.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416688BDBM416688(US10323028, Example 22(a) | (2S)-2-ethoxy-2-[3-(3-...)
Affinity DataIC50: 68.5nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416700BDBM416700(US10323028, Example 33 | US10323028, Example 34 | ...)
Affinity DataIC50: 68.5nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416684BDBM416684(US10323028, Example 20(a) | (2S)-2-[4-Fluoro-3-(tr...)
Affinity DataIC50: 69.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416644BDBM416644(US10323028, Example 3(b) | (2R)-2-Methoxy-2-[3-(3-...)
Affinity DataIC50: 72.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416664BDBM416664(US10323028, Example 10(a) | (2S)-2-[3-(3-Fluoroaze...)
Affinity DataIC50: 72.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416639BDBM416639(US10323028, Example 1(b) | (2R)-2-[3-(3-Fluoroazet...)
Affinity DataIC50: 72.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416670BDBM416670(US10323028, Example 13(a) | (2S)-2-Methoxy-2-[3-(3...)
Affinity DataIC50: 75.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416702BDBM416702(US10323028, Example 35 | US10323028, Example 36 | ...)
Affinity DataIC50: 77nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416674BDBM416674(US10323028, Example 15(a) | (2S)-2-[3-(3-Fluoroaze...)
Affinity DataIC50: 77.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416641BDBM416641(US10323028, Example 2(a) | (2S)-2-[3-(3,3-Difluoro...)
Affinity DataIC50: 87.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416672BDBM416672(US10323028, Example 14(a) | (2S)-2-[3-(3,3-Difluor...)
Affinity DataIC50: 91.5nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416683BDBM416683(US10323028, Example 19(b) | (2R)-2-Ethoxy-N-[5-[[(...)
Affinity DataIC50: 96.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416698BDBM416698(US10323028, Example 31 | 2-ethoxy-2-[3-(3-fluoroaz...)
Affinity DataIC50: 96.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416642BDBM416642(US10323028, Example 2(b) | (2R)-2-[3-(3,3-Difluoro...)
Affinity DataIC50: 121nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416681BDBM416681(US10323028, Example 18(b) | (2R)-2-Methoxy-2-[3-(o...)
Affinity DataIC50: 129nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416706BDBM416706(US10323028, Example 39 | 2-[3-(3,3-difluoroazetidi...)
Affinity DataIC50: 130nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416653BDBM416653(US10323028, Example 5(b) | (2R)-3-Methoxy-2-(3-met...)
Affinity DataIC50: 130nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416689BDBM416689(US10323028, Example 22(b) | (2R)-2-ethoxy-2-[3-(3-...)
Affinity DataIC50: 131nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416700BDBM416700(US10323028, Example 33 | US10323028, Example 34 | ...)
Affinity DataIC50: 131nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416713BDBM416713(US10323028, Example 45(b) | (2R)-3-Methoxy-N-[5-[[...)
Affinity DataIC50: 146nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416704BDBM416704(US10323028, Example 37 | US10323028, Example 38 | ...)
Affinity DataIC50: 147nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416694BDBM416694(US10323028, Example 27 | US10323028, Example 28 | ...)
Affinity DataIC50: 149nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416679BDBM416679(US10323028, Example 17(b) | (2R)-[3-(Difluorometho...)
Affinity DataIC50: 157nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetGlutaminase kidney isoform, mitochondrial(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 416698BDBM416698(US10323028, Example 31 | 2-ethoxy-2-[3-(3-fluoroaz...)
Affinity DataIC50: 188nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

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