Compile Data Set for Download or QSAR
Report error Found 426 Enz. Inhib. hit(s) with all data for entry = 8687
TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413341BDBM413341((S)-6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl...)
Affinity DataIC50: 1.78nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413007BDBM413007(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50: 2.14nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413146BDBM413146(2-fluoro-4-(5-hydroxy-1-(5-(morpholine-4-carbonyl)...)
Affinity DataIC50: 2.24nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413152BDBM413152(2-fluoro-4-(5-hydroxy-1-(5-(4-methyl-4,7-diazaspir...)
Affinity DataIC50: 2.34nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413246BDBM413246(4-(5-hydroxy-1-(5-(4-propylpiperazine-1-carbonyl)p...)
Affinity DataIC50: 2.51nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413353BDBM413353((S)-6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyr...)
Affinity DataIC50: 2.51nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413134BDBM413134(2-fluoro-4-(5-hydroxy-1-(5-(4-methylpiperazine-1-c...)
Affinity DataIC50: 2.57nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413193BDBM413193((S)-4-(1-(5-(3-((2,2-difluoroethyl)(methyl)amino)p...)
Affinity DataIC50: 2.82nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413139BDBM413139(2-fluoro-4-(5-hydroxy-1-(5-(4-methyl-4,7-diazaspir...)
Affinity DataIC50: 2.88nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413210BDBM413210((R)-4-(1-(5-(3-((2,2-difluoroethyl)(methyl)amino)p...)
Affinity DataIC50: 2.95nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413140BDBM413140((S)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...)
Affinity DataIC50: 3.02nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413063BDBM413063(4-(1-(5-(4-(2,2-difluoroethyl)piperazine-1-carbony...)
Affinity DataIC50: 3.09nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413169BDBM413169((S)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...)
Affinity DataIC50: 3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413069BDBM413069(4-(5-hydroxy-1-(5-(4-(2,2,2-trifluoroethyl)piperaz...)
Affinity DataIC50: 3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413199BDBM413199((R)-2-fluoro-4-(5-hydroxy-1-(5-(octahydropyrrolo[1...)
Affinity DataIC50: 3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413158BDBM413158((S)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...)
Affinity DataIC50: 3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413194BDBM413194(6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1...)
Affinity DataIC50: 3.24nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413340BDBM413340(6-(4-(4-cyano-2-fluorophenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50: 3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413200BDBM413200(US10407409, Example 288 | 4-(5-hydroxy-1-(5-(octah...)
Affinity DataIC50: 3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413128BDBM413128((R)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...)
Affinity DataIC50: 3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413188BDBM413188(6-(4-(4-cyano-5-fluoro-2-methylphenyl)-5-hydroxy-1...)
Affinity DataIC50: 3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413187BDBM413187((S)-2-fluoro-4-(5-hydroxy-1-(5-(3-(methyl(2,2,2-tr...)
Affinity DataIC50: 3.39nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413157BDBM413157(2-fluoro-4-(5-hydroxy-1-(5-(morpholine-4-carbonyl)...)
Affinity DataIC50: 3.39nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413239BDBM413239((S)-4-(1-(5-(4-ethyl-2-methylpiperazine-1-carbonyl...)
Affinity DataIC50: 3.39nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 412995BDBM412995(US10407409, Example 299 | 4-(1-(5-(6,6-difluoro-4-...)
Affinity DataIC50: 3.47nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413335BDBM413335((R)-6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl...)
Affinity DataIC50: 3.47nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413347BDBM413347((R)-6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyr...)
Affinity DataIC50: 3.55nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413164BDBM413164((R)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...)
Affinity DataIC50: 3.63nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413023BDBM413023(4-(5-hydroxy-1-(5-(3,3,4-trimethylpiperazine-1-car...)
Affinity DataIC50: 3.63nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413145BDBM413145(2-fluoro-4-(5-hydroxy-1-(5-(pyrrolidine-1-carbonyl...)
Affinity DataIC50: 3.63nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413205BDBM413205(2-fluoro-4-(5-hydroxy-1-(5-(3-(piperidin-1-yl)azet...)
Affinity DataIC50: 3.72nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413011BDBM413011(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50: 3.89nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413246BDBM413246(4-(5-hydroxy-1-(5-(4-propylpiperazine-1-carbonyl)p...)
Affinity DataIC50: 3.89nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413104BDBM413104(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50: 3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413121BDBM413121(4-(1-(5-(3-(dimethylamino)azetidine-1-carbonyl)pyr...)
Affinity DataIC50: 3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413148BDBM413148(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50: 3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413098BDBM413098(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50: 3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413221BDBM413221((R)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...)
Affinity DataIC50: 3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413223BDBM413223(6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50: 3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413233BDBM413233((R)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...)
Affinity DataIC50: 4.07nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413039BDBM413039(4-(1-(5-(4-cyclopropylpiperazine-1-carbonyl)pyridi...)
Affinity DataIC50: 4.07nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 412984BDBM412984(US10407409, Example 297 | 4-(1-(5-(3-(cyclobutyl(m...)
Affinity DataIC50: 4.07nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413240BDBM413240(4-(1-(5-(4-cyclopropylpiperazine-1-carbonyl)pyridi...)
Affinity DataIC50: 4.07nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413163BDBM413163((S)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...)
Affinity DataIC50: 4.07nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413216BDBM413216((R)-2-fluoro-4-(5-hydroxy-1-(5-(4-isopropyl-3-meth...)
Affinity DataIC50: 4.37nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413317BDBM413317(6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl)-N-...)
Affinity DataIC50: 4.37nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413105BDBM413105((S)-4-(1-(5-(3-(dimethylamino)pyrrolidine-1-carbon...)
Affinity DataIC50: 4.47nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413263BDBM413263(4-(1-(5-(3-(dimethylamino)azetidine-1-carbonyl)pyr...)
Affinity DataIC50: 4.47nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413175BDBM413175((R)-4-(1-(5-(4-ethyl-2-methylpiperazine-1-carbonyl...)
Affinity DataIC50: 4.57nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 413133BDBM413133(4-(1-(5-(4-cyclopropyl-1,4-diazepane-1-carbonyl)py...)
Affinity DataIC50: 4.68nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

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