Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 8996
TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434982BDBM434982(US10584104, Compound of Example 51 | US11149013, C...)
Affinity DataIC50: 81nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434983BDBM434983(US10584104, Compound of Example 52)
Affinity DataIC50: 83nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434973BDBM434973(US10584104, Compound of Example 10)
Affinity DataIC50: 94nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434978BDBM434978(US10584104, Compound of Example 38)
Affinity DataIC50: 107nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434970BDBM434970(US10584104, Compound of Example 2)
Affinity DataIC50: 193nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434969BDBM434969(US10584104, Compound of Example 1)
Affinity DataIC50: 201nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434979BDBM434979(US10584104, Compound of Example 39)
Affinity DataIC50: 381nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434971BDBM434971(US10584104, Compound of Example 5)
Affinity DataIC50: 418nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434972BDBM434972(US10584104, Compound of Example 6)
Affinity DataIC50: 440nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434974BDBM434974(US10584104, Compound of Example 11)
Affinity DataIC50: 484nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434981BDBM434981(US10584104, Compound of Example 49)
Affinity DataIC50: 487nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434980BDBM434980(US10584104, Compound of Example 48)
Affinity DataIC50: 512nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434976BDBM434976(US10584104, Compound of Example 20)
Affinity DataIC50: 886nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434977BDBM434977(US10584104, Compound of Example 25)
Affinity DataIC50: 1.01E+3nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434975BDBM434975(US10584104, Compound of Example 17)
Affinity DataIC50: 1.02E+3nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434968BDBM434968(US10584104, Compound B)
Affinity DataIC50: 1.81E+3nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434966BDBM434966(US10584104, Compound A)
Affinity DataIC50: 2.13E+3nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Tianjin Institute of Pharmaceutical Research

US Patent
LigandChemical structure of BindingDB Monomer ID 434965BDBM434965(US10584104, Compound lesinurad)
Affinity DataIC50: 7.18E+3nMAssay Description:After trypsin digestion, the expression cells (HEK293) stably expressing URAT1 gene and mock cells were all inoculated into lysine-coated 24-well cul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent