Compile Data Set for Download or QSAR
Report error Found 279 Enz. Inhib. hit(s) with all data for entry = 9027
TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 436071BDBM436071(US10611766, Example 23-isomer-2 | US10611766, Exam...)
Affinity DataIC50: 0.400nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412836BDBM412836(US10399989, Example 49 | N-[[4-(4-amino-1-cyclohex...)
Affinity DataIC50: 0.400nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412838BDBM412838(US10399989, Example 51 | N-[[4-(4-amino-1-tert-but...)
Affinity DataIC50: 0.600nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412841BDBM412841(US10399989, Example 54 | N-[[4-[4-amino-1-[(1R,4R)...)
Affinity DataIC50: 0.700nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412788BDBM412788(US10399989, Example 4 | N-[[4-(4-amino-1-cyclopent...)
Affinity DataIC50: 0.800nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412843BDBM412843(US10399989, Example 56 | N-[[4-[4-amino-1-[(1R)-in...)
Affinity DataIC50: 1.20nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412828BDBM412828(US10399989, Example 41 | Ethyl 3-[4-amino-3-[4-[[(...)
Affinity DataIC50: 1.20nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412816BDBM412816(US10399989, Example 30 | N-[[4-[4-amino-1-[(1R,4R)...)
Affinity DataIC50: 1.40nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412826BDBM412826(US10399989, Example 39 | N-[[4-[4-amino-1-(4-metho...)
Affinity DataIC50: 1.40nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412824BDBM412824(US10399989, Example 37 | N-[[4-[4-amino-1-(3-hydro...)
Affinity DataIC50: 1.70nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412810BDBM412810(US10399989, Example 24 | N-[[4-[4-amino-1-[(1R*,3S...)
Affinity DataIC50: 2.20nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412853BDBM412853(US10399989, Example 66 | N-[[4-(4-amino-1-cyclopen...)
Affinity DataIC50: 4nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412788BDBM412788(US10399989, Example 4 | N-[[4-(4-amino-1-cyclopent...)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412881BDBM412881(US10399989, Example 94 | US10611766, Example 95)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412788BDBM412788(US10399989, Example 4 | N-[[4-(4-amino-1-cyclopent...)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412881BDBM412881(US10399989, Example 94 | US10611766, Example 95)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412881BDBM412881(US10399989, Example 94 | US10611766, Example 95)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412880BDBM412880(US10399989, Example 93 | US10611766, Example 93)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412880BDBM412880(US10399989, Example 93 | US10611766, Example 93)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412881BDBM412881(US10399989, Example 94 | US10611766, Example 95)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412878BDBM412878(US10399989, Example 91 | US10611766, Example 92)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412785BDBM412785(US10399989, Example 1 | US10611766, Example 1)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412878BDBM412878(US10399989, Example 91 | US10611766, Example 92)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412785BDBM412785(US10399989, Example 1 | US10611766, Example 1)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412796BDBM412796(US10399989, Example 12 | US10611766, Example 12)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412796BDBM412796(US10399989, Example 12 | US10611766, Example 12)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412795BDBM412795(US10399989, Example 11 | US10611766, Example 11)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412795BDBM412795(US10399989, Example 11 | US10611766, Example 11)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 436055BDBM436055(US10611766, Example 8)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412791BDBM412791(US10399989, Example 7 | US10611766, Example 7)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412791BDBM412791(US10399989, Example 7 | US10611766, Example 7)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412804BDBM412804(US10399989, Example 19 | US10611766, Example 19)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412804BDBM412804(US10399989, Example 19 | US10611766, Example 19)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412810BDBM412810(US10399989, Example 24 | N-[[4-[4-amino-1-[(1R*,3S...)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412810BDBM412810(US10399989, Example 24 | N-[[4-[4-amino-1-[(1R*,3S...)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 436070BDBM436070(US10611766, Example 23-isomer1)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 436071BDBM436071(US10611766, Example 23-isomer-2 | US10611766, Exam...)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 436071BDBM436071(US10611766, Example 23-isomer-2 | US10611766, Exam...)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 436070BDBM436070(US10611766, Example 23-isomer1)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412806BDBM412806(US10399989, Example 21 | US10611766, Example 21)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412806BDBM412806(US10399989, Example 21 | US10611766, Example 21)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412815BDBM412815(US10399989, Example 29 | US10611766, Example 29)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412815BDBM412815(US10399989, Example 29 | US10611766, Example 29)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412816BDBM412816(US10399989, Example 30 | N-[[4-[4-amino-1-[(1R,4R)...)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412812BDBM412812(US10399989, Example 26 | US10611766, Example 26)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412811BDBM412811(US10399989, Example 25 | US10611766, Example 25)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412811BDBM412811(US10399989, Example 25 | US10611766, Example 25)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412820BDBM412820(US10399989, Example 33-isomer 2 | US10611766, Exam...)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [C481S](Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412820BDBM412820(US10399989, Example 33-isomer 2 | US10611766, Exam...)
Affinity DataIC50: 10nMAssay Description:BTKC481S binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. ...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Loxo Oncology

US Patent
LigandChemical structure of BindingDB Monomer ID 412820BDBM412820(US10399989, Example 33-isomer 2 | US10611766, Exam...)
Affinity DataIC50: 10nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

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