Compile Data Set for Download or QSAR
Report error Found 114 Enz. Inhib. hit(s) with all data for entry = 9064
LigandChemical structure of BindingDB Monomer ID 279088BDBM279088(US10034861, Example 120 | 5-(2-ethoxy-3-pyridyl)-3...)
Affinity DataIC50: 0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438746BDBM438746(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 0.270nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438746BDBM438746(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 0.470nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438725BDBM438725(21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(...)
Affinity DataIC50: 0.540nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279037BDBM279037(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 0.640nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279168BDBM279168(5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopro...)
Affinity DataIC50: 0.75nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278999BDBM278999(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-...)
Affinity DataIC50: 1.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279039BDBM279039(US10034861, Example 70 | 5-(2-ethoxy-3-pyridyl)-1-...)
Affinity DataIC50: 1.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438722BDBM438722(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 1.40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438723BDBM438723(21-isopropyl-23-methyl-21H-6,12-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 1.5nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278971BDBM278971(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 1.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279116BDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50: 2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279153BDBM279153(3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isop...)
Affinity DataIC50: 2.40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438725BDBM438725(21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279137BDBM279137(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50: 2.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438746BDBM438746(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 3.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438724BDBM438724(21-isopropyl-23-methyl-21H-6,10-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 4.20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279088BDBM279088(US10034861, Example 120 | 5-(2-ethoxy-3-pyridyl)-3...)
Affinity DataIC50: 4.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438735BDBM438735(21-isopropyl-23-methyl-21H,51H-11-oxa-3-aza- 2(5,7...)
Affinity DataIC50: 4.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279082BDBM279082(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(2-methylthiazo...)
Affinity DataIC50: 5.70nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279134BDBM279134(N-[[1-(difluoromethyl)pyrazol-4-yl]methyl]-5-(2-et...)
Affinity DataIC50: 5.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279018BDBM279018(5-(2-ethoxypyridin-3-yl)-1-ethyl-3-methyl-N-((1-me...)
Affinity DataIC50: 6.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 425070BDBM425070(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(2-...)
Affinity DataIC50: 6.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279168BDBM279168(5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopro...)
Affinity DataIC50: 7.40nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279088BDBM279088(US10034861, Example 120 | 5-(2-ethoxy-3-pyridyl)-3...)
Affinity DataIC50: 7.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279037BDBM279037(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 9.60nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438750BDBM438750(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279116BDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50: 12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438722BDBM438722(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279166BDBM279166(5-(2-ethoxy-3-pyridyl)-N-[(2-methoxy-3-pyridyl)met...)
Affinity DataIC50: 13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279153BDBM279153(3-(difluoromethyl)-5-(2-ethoxypyridin-3-yl)-1-isop...)
Affinity DataIC50: 13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278999BDBM278999(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-...)
Affinity DataIC50: 13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279137BDBM279137(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50: 14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279132BDBM279132(5-(2-ethoxy-3-pyridyl)-3-methyl-N-[(1-methyl-1,2,4...)
Affinity DataIC50: 14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279039BDBM279039(US10034861, Example 70 | 5-(2-ethoxy-3-pyridyl)-1-...)
Affinity DataIC50: 14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438749BDBM438749(21-isopropyl-23-methyl-21H,51H-10-oxa-3-aza- 2(5,7...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278983BDBM278983(5-(2-ethoxy-3-pyridyl)-N-[(1-methylpyrazol-4-yl)me...)
Affinity DataIC50: 15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438725BDBM438725(21-isopropyl-23-methyl-21H-6,9,12-trioxa-3- aza-2(...)
Affinity DataIC50: 16nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438750BDBM438750(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438723BDBM438723(21-isopropyl-23-methyl-21H-6,12-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278971BDBM278971(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(5-...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279169BDBM279169(1-isopropyl-3-methyl-N-((1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 18nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438722BDBM438722(21-isopropyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7...)
Affinity DataIC50: 20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 424936BDBM424936(US10512632, Example 26 | US10618913, Example S26 |...)
Affinity DataIC50: 22nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438735BDBM438735(21-isopropyl-23-methyl-21H,51H-11-oxa-3-aza- 2(5,7...)
Affinity DataIC50: 25nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279168BDBM279168(5-(2-ethoxypyridin-3-yl)-3-(fluoromethyl)-1-isopro...)
Affinity DataIC50: 26nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 278999BDBM278999(5-(2-ethoxy-3-pyridyl)-1-isopropyl-3-methyl-N-[(4-...)
Affinity DataIC50: 27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279037BDBM279037(5-(2-ethoxy-3-pyridyl)-3-methyl-1-[1-methylpropyl]...)
Affinity DataIC50: 27nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 279116BDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50: 28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 438748BDBM438748(21-ethyl-23-methyl-21H-6,11-dioxa-3-aza- 2(5,7)-py...)
Affinity DataIC50: 36nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

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