Compile Data Set for Download or QSAR
Report error Found 360 Enz. Inhib. hit(s) with all data for entry = 9233
LigandPNGBDBM451038(US10676479, Example 68 | 8-(4-((dimethylamino)meth...)
Affinity DataIC50: 0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451065(US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 0.100nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451070(US10676479, Example 100 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 0.600nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451062(US10676479, Example 92 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 0.700nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451065(US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 2nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450978(US10676479, Example 10 | 1-Chloro-8-(2,4-dimethylp...)
Affinity DataIC50: 2nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451074(US10676479, Example 104 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 2.10nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450981(US10676479, Example 13 | 8-(2-(Difluoromethyl)pyri...)
Affinity DataIC50: 2.30nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451053(US10676479, Example 83 | 8-(2-(3,5-dimethylpiperaz...)
Affinity DataIC50: 2.30nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451054(US10676479, Example 84 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451072(US10676479, Example 102 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.40nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451056(US10676479, Example 86 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451088(US10676479, Example 118 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.60nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451055(US10676479, Example 85 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 2.80nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451074(US10676479, Example 104 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 3nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450969(US10676479, Example 6 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.10nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450968(US10676479, Example 5 | 8-(1,3-Dimethyl-1H-pyrazol...)
Affinity DataIC50: 3.20nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451025(US10676479, Example 55 | 8-(4-(azetidin-1-ylmethyl...)
Affinity DataIC50: 3.30nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451058(US10676479, Example 88 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 3.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450968(US10676479, Example 5 | 8-(1,3-Dimethyl-1H-pyrazol...)
Affinity DataIC50: 3.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451064(US10676479, Example 94 | ethyl 8-(2,4-dimethylpyri...)
Affinity DataIC50: 3.60nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451071(US10676479, Example 101 | 8-(2,4-dimethylpyrimidin...)
Affinity DataIC50: 3.60nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451032(US10676479, Example 62 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 3.70nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450981(US10676479, Example 13 | 8-(2-(Difluoromethyl)pyri...)
Affinity DataIC50: 3.70nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451085(US10676479, Example 115 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 4nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451041(US10676479, Example 71 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 4.10nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450969(US10676479, Example 6 | 5-(((5-Fluoro-2,3-dihydrob...)
Affinity DataIC50: 4.20nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451064(US10676479, Example 94 | ethyl 8-(2,4-dimethylpyri...)
Affinity DataIC50: 4.30nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451024(US10676479, Example 54 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 4.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451070(US10676479, Example 100 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 4.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451056(US10676479, Example 86 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 4.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451055(US10676479, Example 85 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 4.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451026(US10676479, Example 56 | 2,2-difluoro-2-(5-(5-(((5...)
Affinity DataIC50: 4.80nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451088(US10676479, Example 118 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 4.80nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450982(US10676479, Example 14 | 8-(2,4-dimethylpyrimidin-...)
Affinity DataIC50: 4.90nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451063(US10676479, Example 93 | ethyl 8-(2,6-dimethylpyri...)
Affinity DataIC50: 4.90nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451073(US10676479, Example 103 | 8-bromo-N-((5-fluoro-2,3...)
Affinity DataIC50: 5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451070(US10676479, Example 100 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451063(US10676479, Example 93 | ethyl 8-(2,6-dimethylpyri...)
Affinity DataIC50: 5.10nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451048(US10676479, Example 78 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5.10nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451015(US10676479, Example 45 | 8-(1,3-dimethyl-1H-pyrazo...)
Affinity DataIC50: 5.10nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451021(US10676479, Example 51 | 8-(2-(difluoromethyl)pyri...)
Affinity DataIC50: 5.20nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451049(US10676479, Example 79 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5.30nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451046(US10676479, Example 76 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5.40nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450980(US10676479, Example 12 | US10676479, Example 69 | ...)
Affinity DataIC50: 5.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451062(US10676479, Example 92 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 5.40nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451088(US10676479, Example 118 | N-((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5.5nMAssay Description:Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM450991(US10676479, Example 22 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 5.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451065(US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...)
Affinity DataIC50: 5.5nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

LigandPNGBDBM451046(US10676479, Example 76 | 5-(((5-fluoro-2,3-dihydro...)
Affinity DataIC50: 5.60nMAssay Description:To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2021
Entry Details
US Patent

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