Compile Data Set for Download or QSAR
Report error Found 61 Enz. Inhib. hit(s) with all data for entry = 9201
LigandChemical structure of BindingDB Monomer ID 448752BDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448752BDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448752BDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448752BDBM448752(US10696665, Example 21 | (4S)-3-[2-[[(1S)-1-[4-[2-...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448754BDBM448754(3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-enoylp...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448754BDBM448754(3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-enoylp...)
Affinity DataIC50: 5.08nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503281BDBM50503281(US10696665, Example 25 | CHEMBL4586919)
Affinity DataIC50: 8.89nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503281BDBM50503281(US10696665, Example 25 | CHEMBL4586919)
Affinity DataIC50: 11nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448758BDBM448758(4R)-3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-en...)
Affinity DataIC50: 12.5nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503281BDBM50503281(US10696665, Example 25 | CHEMBL4586919)
Affinity DataIC50: 18nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448758BDBM448758(4R)-3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-en...)
Affinity DataIC50: 18.2nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448732BDBM448732((S)-3-(2-(((S)-1-(4-((4-Acryloylpiperazin-1-yl)met...)
Affinity DataIC50: 19.2nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448754BDBM448754(3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-enoylp...)
Affinity DataIC50: 21.9nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448738BDBM448738((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 22.3nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448734BDBM448734((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 24.2nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 146427BDBM146427(US8957068, 556 | US10696665, Art compound)
Affinity DataIC50: 25.2nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448754BDBM448754(3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-enoylp...)
Affinity DataIC50: 25.6nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448738BDBM448738((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 27.6nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448734BDBM448734((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 30.6nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448737BDBM448737((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 35.3nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448751BDBM448751((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 35.3nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448732BDBM448732((S)-3-(2-(((S)-1-(4-((4-Acryloylpiperazin-1-yl)met...)
Affinity DataIC50: 36.4nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503281BDBM50503281(US10696665, Example 25 | CHEMBL4586919)
Affinity DataIC50: 38.5nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448737BDBM448737((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 46.6nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448751BDBM448751((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 50.1nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 146427BDBM146427(US8957068, 556 | US10696665, Art compound)
Affinity DataIC50: 51nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448744BDBM448744((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 56.8nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503272BDBM50503272(US10696665, Example 11 | CHEMBL4574029)
Affinity DataIC50: 83.5nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448744BDBM448744((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 84.6nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448746BDBM448746((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 90.9nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503271BDBM50503271(US10696665, Example 4 | CHEMBL4550083)
Affinity DataIC50: 96.8nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448741BDBM448741((S)-3-(2-(1-(4-((4- acryloylpiperazin-1- yl)methyl...)
Affinity DataIC50: 101nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448746BDBM448746((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 102nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503272BDBM50503272(US10696665, Example 11 | CHEMBL4574029)
Affinity DataIC50: 109nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448747BDBM448747((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 123nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448748BDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 125nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503271BDBM50503271(US10696665, Example 4 | CHEMBL4550083)
Affinity DataIC50: 141nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Eli Lilly

US Patent
LigandChemical structure of BindingDB Monomer ID 448758BDBM448758(4R)-3-[2-[[(1S)-1-[4-[2-Cyclopropyl-1-(4-prop-2-en...)
Affinity DataIC50: 145nMAssay Description:Wild-Type IDH1: Enzymes catalyze the conversion of isocitrate to αKG. Wild-type IDH1 (National Center for Biotechnology Information, Accession: ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448739BDBM448739((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 149nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448741BDBM448741((S)-3-(2-(1-(4-((4- acryloylpiperazin-1- yl)methyl...)
Affinity DataIC50: 176nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448742BDBM448742(3-(2-((1-(4-((4- acryloylpiperazin-1-yl) methyl)ph...)
Affinity DataIC50: 187nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448750BDBM448750((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 194nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448750BDBM448750((R)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 206nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448735BDBM448735((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 210nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448735BDBM448735((S)-3-(2-(((S)-1-(4-((4- acryloylpiperazin-1- yl)m...)
Affinity DataIC50: 246nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448740BDBM448740((S)-3-(2-((1-(4-((4- acryloylpiperazin-1- yl)methy...)
Affinity DataIC50: 250nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448742BDBM448742(3-(2-((1-(4-((4- acryloylpiperazin-1-yl) methyl)ph...)
Affinity DataIC50: 261nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50503273BDBM50503273(US10696665, Example 13 | CHEMBL4571722)
Affinity DataIC50: 272nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448748BDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 273nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 448748BDBM448748(US10696665, Example 17 | 3-(2-(((1S)-1-(4-(1-(4- a...)
Affinity DataIC50: 291nMAssay Description:IDH1 mutant (R132H and R132C) and IDH2 mutant (R140Q and R172K) proteins containing N-terminal His-tag are expressed in E. coli and purified using ni...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

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