Compile Data Set for Download or QSAR
Report error Found 607 Enz. Inhib. hit(s) with all data for entry = 9434
TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466496BDBM466496([3-(Hydroxymethyl)-1,1-Dioxo-Thietan-3-Yl]Methyl (...)
Affinity DataEC50:  0.200nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466494BDBM466494([3,3-Difluoro-1-(Hydroxymethyl)Cyclobutyl]Methyl (...)
Affinity DataEC50:  0.300nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466484BDBM466484((8S)-N-[(1S,2S)-2- (3,4- difluorophenyl)-2- hydrox...)
Affinity DataEC50:  0.400nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466344BDBM466344((8S)-N-(2- cyclohexyl-2- hydroxy-ethyl)-5- (7H-pyr...)
Affinity DataEC50:  0.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466343BDBM466343((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Affinity DataEC50:  0.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466495BDBM466495([1-(Hydroxymethyl)Cyclohexyl]Methyl (8S)-5-(7H-Pyr...)
Affinity DataEC50:  0.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466346BDBM466346((8S)-N-[(2S)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Affinity DataEC50:  0.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466345BDBM466345((8S)-N-[(1S,2S)-2- cyclohexyl-2- hydroxy-1- methyl...)
Affinity DataEC50:  0.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466493BDBM466493([1-(Hydroxymethyl)Cyclopentyl]Methyl (8S)-5-(7H-Py...)
Affinity DataEC50:  0.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466348BDBM466348((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Affinity DataEC50:  0.600nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466496BDBM466496([3-(Hydroxymethyl)-1,1-Dioxo-Thietan-3-Yl]Methyl (...)
Affinity DataEC50:  0.600nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466347BDBM466347((8S) N-[(1S,2S)-2-Cyclopentyl-2-Hydroxy-1-Methyl-E...)
Affinity DataEC50:  0.600nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466350BDBM466350((8S)-N-[(2S)-2-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Affinity DataEC50:  0.600nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466349BDBM466349((8S)-N-[(2S)-2-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Affinity DataEC50:  0.600nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466484BDBM466484((8S)-N-[(1S,2S)-2- (3,4- difluorophenyl)-2- hydrox...)
Affinity DataEC50:  0.600nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466351BDBM466351((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Affinity DataEC50:  0.700nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466352BDBM466352((8S)-N-[(2R)-2- hydroxy-2- tetrahydropyran- 4-yl-e...)
Affinity DataEC50:  0.800nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466492BDBM466492([1-(hydroxymethyl)cyclobutyl]methyl (8S)-5-(7H-pyr...)
Affinity DataEC50:  0.800nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466354BDBM466354((8S)-N-[(2R)-2-(5- fluoro-2-pyridyl)- 2-hydroxy-et...)
Affinity DataEC50:  0.800nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466494BDBM466494([3,3-Difluoro-1-(Hydroxymethyl)Cyclobutyl]Methyl (...)
Affinity DataEC50:  0.800nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466353BDBM466353((8S)-N-[(2R)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Affinity DataEC50:  0.800nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466356BDBM466356((8S)-N-[(1S)-1-(4- cyano-3-fluoro- phenyl)ethyl]-5...)
Affinity DataEC50:  0.900nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466355BDBM466355((8S)-N-[(4- cyanophenyl) methyl]-5-(7H- pyrrolo[2,...)
Affinity DataEC50:  0.900nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466357BDBM466357((8S)-N-[(2R)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Affinity DataEC50:  0.900nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466489BDBM466489((3,3-Difluorocyclobutyl)Methyl (8S)-5-(7H-Pyrrolo[...)
Affinity DataEC50:  0.900nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466360BDBM466360((8S)-N-[(1R)-1-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Affinity DataEC50:  1nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466359BDBM466359((8S)-N-[(1R)-1-(4- fluorophenyl)-2- hydroxy-ethyl]...)
Affinity DataEC50:  1nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466343BDBM466343((8S)-N-[(2S)-2- cyclopentyl-2- hydroxy-ethyl]-5- (...)
Affinity DataEC50:  1nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466358BDBM466358((8S)-N-[(4-cyano- 3-fluoro- phenyl)methyl]-5- (7H-...)
Affinity DataEC50:  1nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466363BDBM466363(N-[(1S)-1-(4- cyanophenyl) ethyl]-5-(7H- pyrrolo[2...)
Affinity DataEC50:  1.10nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466347BDBM466347((8S) N-[(1S,2S)-2-Cyclopentyl-2-Hydroxy-1-Methyl-E...)
Affinity DataEC50:  1.10nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466362BDBM466362((8S)-N-[(1S)-1-(4- cyano-2-fluoro- phenyl)ethyl]-5...)
Affinity DataEC50:  1.10nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466361BDBM466361(N-[(1R)-1-(4- cyanophenyl)-2- hydroxy-ethyl]-5- (7...)
Affinity DataEC50:  1.10nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466345BDBM466345((8S)-N-[(1S,2S)-2- cyclohexyl-2- hydroxy-1- methyl...)
Affinity DataEC50:  1.10nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466364BDBM466364((8S)-N-[(1S)-1-(4- cyanophenyl) ethyl]-5-(7H- pyrr...)
Affinity DataEC50:  1.20nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466346BDBM466346((8S)-N-[(2S)-2- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Affinity DataEC50:  1.20nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466344BDBM466344((8S)-N-(2- cyclohexyl-2- hydroxy-ethyl)-5- (7H-pyr...)
Affinity DataEC50:  1.30nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466367BDBM466367((8S)-N-[(2R)-2- cyclobutyl-2- hydroxy-ethyl]-5- (7...)
Affinity DataEC50:  1.30nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466366BDBM466366((8S)-N-[(1R)-1- cyclohexyl-2- hydroxy-ethyl]-5- (7...)
Affinity DataEC50:  1.30nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466365BDBM466365((8S)-N-[[3,3- difluoro-1- (hydroxymethyl) cyclobut...)
Affinity DataEC50:  1.30nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466493BDBM466493([1-(Hydroxymethyl)Cyclopentyl]Methyl (8S)-5-(7H-Py...)
Affinity DataEC50:  1.30nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466368BDBM466368(N-[(4- cyanophenyl) methyl]-5-(7H- pyrrolo[2,3- d]...)
Affinity DataEC50:  1.40nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466372BDBM466372((8S)-N-[(1S,2S)-2- (5-fluoro-2- pyridyl)-2- hydrox...)
Affinity DataEC50:  1.40nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466348BDBM466348((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Affinity DataEC50:  1.40nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466371BDBM466371((8S)-N-[(2R)-2-(4- cyanophenyl)-2- hydroxy-ethyl]-...)
Affinity DataEC50:  1.40nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466370BDBM466370((8S)-N-[(1R)-1-(4- cyanophenyl)-2- hydroxy-1- meth...)
Affinity DataEC50:  1.40nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466369BDBM466369((8S)-N-[(1S)-1-(4- cyanophenyl)-2- hydroxy-1- meth...)
Affinity DataEC50:  1.40nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466373BDBM466373((8S)-N-[(4-cyano- 2-fluoro- phenyl)methyl]-5- (7H-...)
Affinity DataEC50:  1.40nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466496BDBM466496([3-(Hydroxymethyl)-1,1-Dioxo-Thietan-3-Yl]Methyl (...)
Affinity DataEC50:  1.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Leo Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 466351BDBM466351((8S)-N-[(1S,2S)-2- (4-fluorophenyl)- 2-hydroxy-1- ...)
Affinity DataEC50:  1.60nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

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