Compile Data Set for Download or QSAR
Report error Found 1146 Enz. Inhib. hit(s) with all data for entry = 9490
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374029BDBM374029(US10246453, Example 297 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 2nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374015BDBM374015(US10246453, Example 282 | (R)-2,6-difluoro-3-methy...)
Affinity DataIC50: 5nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374015BDBM374015(US10246453, Example 282 | (R)-2,6-difluoro-3-methy...)
Affinity DataIC50: 5nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373891BDBM373891(US10246453, Example 158 | (S)-4-((1-benzyl-3-methy...)
Affinity DataIC50: 8nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374028BDBM374028(US10246453, Example 295 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 9nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373891BDBM373891(US10246453, Example 158 | (S)-4-((1-benzyl-3-methy...)
Affinity DataIC50: 9nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373956BDBM373956(US10246453, Example 223 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 9nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374029BDBM374029(US10246453, Example 297 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 10nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374012BDBM374012(US10246453, Example 279 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 11nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 470683BDBM470683((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Affinity DataIC50: 11nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 444553BDBM444553(US10662184, Example 297 | (S)-3-chloro-2,6-difluor...)
Affinity DataIC50: 12nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373764BDBM373764(US10246453, Example 31 | (S)-3-chloro-4-((1-(3-(di...)
Affinity DataIC50: 13nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 470682BDBM470682((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Affinity DataIC50: 17nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373768BDBM373768(US10246453, Example 35 | (S)-3-chloro-4-((1-(2-flu...)
Affinity DataIC50: 21nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374014BDBM374014(US10246453, Example 281 | (R)-2-fluoro-5-methyl-4-...)
Affinity DataIC50: 21nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373763BDBM373763(US10246453, Example 30 | (S)-3-chloro-4-((1-(3-chl...)
Affinity DataIC50: 21nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373957BDBM373957(US10246453, Example 224 | (S)-2,6-difluoro-3-methy...)
Affinity DataIC50: 24nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 444506BDBM444506(US10662184, Example 74 | 4-((trans-1-benzyl-4-meth...)
Affinity DataIC50: 25nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 470683BDBM470683((S)-2,6-difluoro-3-methyl-4-(methyl(1-((6-methylpy...)
Affinity DataIC50: 26nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374010BDBM374010(US10246453, Example 277 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 27nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373816BDBM373816(US10246453, Example 83 | (S)-3-chloro-4-(methyl(1-...)
Affinity DataIC50: 29nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373764BDBM373764(US10246453, Example 31 | (S)-3-chloro-4-((1-(3-(di...)
Affinity DataIC50: 29nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373749BDBM373749(US10246453, Example 16 | 4-(((1R,3s,5S)-8-benzyl-8...)
Affinity DataIC50: 30nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373961BDBM373961(US10246453, Example 228 | rac-4-((1-benzyl-3-methy...)
Affinity DataIC50: 31nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373788BDBM373788(US10246453, Example 55 | (R)-3-chloro-4-((1-(1-phe...)
Affinity DataIC50: 32nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373838BDBM373838(US10246453, Example 105 | 4-((1-benzylpiperidin-4-...)
Affinity DataIC50: 34nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373816BDBM373816(US10246453, Example 83 | (S)-3-chloro-4-(methyl(1-...)
Affinity DataIC50: 36nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373761BDBM373761(US10246453, Example 28 | (S)-3-chloro-4-((1-(3-(di...)
Affinity DataIC50: 36nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374016BDBM374016(US10246453, Example 283 | (R)-2,6-difluoro-3-methy...)
Affinity DataIC50: 37nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373821BDBM373821(US10246453, Example 88 | (R)-5-chloro-2-fluoro-4-(...)
Affinity DataIC50: 39nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373767BDBM373767(US10246453, Example 34 | (S)-3-chloro-4-((1-(2-flu...)
Affinity DataIC50: 39nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373766BDBM373766(US10246453, Example 33 | (S)-3-chloro-4-((1-(5-chl...)
Affinity DataIC50: 41nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374031BDBM374031(US10246453, Example 298 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 43nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373968BDBM373968(US10246453, Example 235 | (S)-2,6-difluoro-4-((1-(...)
Affinity DataIC50: 47nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373765BDBM373765(US10246453, Example 32 | (S)-3-chloro-4-((1-(3-chl...)
Affinity DataIC50: 47nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373840BDBM373840(US10246453, Example 107 | (S)-2-fluoro-4-((1-((2-i...)
Affinity DataIC50: 49nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373871BDBM373871(US10246453, Example 138 | (S)-4-((1-((2-cyclopropy...)
Affinity DataIC50: 50nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 470680BDBM470680((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-f...)
Affinity DataIC50: 54nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373815BDBM373815(US10246453, Example 82 | 3-chloro-4-(1-((6-methylp...)
Affinity DataIC50: 56nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373851BDBM373851(US10246453, Example 118 | (S)-2-fluoro-5-methyl-4-...)
Affinity DataIC50: 58nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373762BDBM373762(US10246453, Example 29 | (S)-4-((1-benzylpyrrolidi...)
Affinity DataIC50: 60nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 470682BDBM470682((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...)
Affinity DataIC50: 61nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 444553BDBM444553(US10662184, Example 297 | (S)-3-chloro-2,6-difluor...)
Affinity DataIC50: 62nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374012BDBM374012(US10246453, Example 279 | (S)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 64nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373970BDBM373970(US10246453, Example 237 | (S)-4-((1-(2,3-difluorob...)
Affinity DataIC50: 64nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374000BDBM374000(US10246453, Example 267 | (S)-3-chloro-2,6-difluor...)
Affinity DataIC50: 66nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373969BDBM373969(US10246453, Example 236 | (S)-2,6-difluoro-4-((1-(...)
Affinity DataIC50: 67nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 374016BDBM374016(US10246453, Example 283 | (R)-2,6-difluoro-3-methy...)
Affinity DataIC50: 67nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 373760BDBM373760(US10246453, Example 27 | (S)-3-chloro-4-((1-(3-chl...)
Affinity DataIC50: 70nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

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