Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 9609
TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50536185BDBM50536185(CHEMBL4588910 | US10870625, Compound 57)
Affinity DataIC50: 144nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 476664BDBM476664(US10870625, Compound 54)
Affinity DataIC50: 323nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 476672BDBM476672(US10870625, Compound 59)
Affinity DataIC50: 688nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50190621BDBM50190621(CHEMBL3827532 | US10870625, Compound 15)
Affinity DataIC50: 870nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 476671BDBM476671(US10870625, Compound 58)
Affinity DataIC50: 1.02E+3nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 476668BDBM476668(US10870625, Compound 56)
Affinity DataIC50: 1.45E+3nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50190619BDBM50190619(CHEMBL3827086 | US10870625, Compound 14)
Affinity DataIC50: 1.58E+3nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 476663BDBM476663(US10870625, Compound 29)
Affinity DataIC50: 1.96E+3nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 50536190BDBM50536190(CHEMBL4483336 | US10870625, Compound 55)
Affinity DataIC50: 2.91E+3nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent

TargetDihydrofolate reductase(Human)
University of Connecticut

US Patent
LigandChemical structure of BindingDB Monomer ID 18069BDBM18069(CHEMBL22 | TMP | Trimethoprim (TMP) | 5-[(3,4,5-tr...)
Affinity DataIC50: 9.72E+4nMAssay Description:Enzyme activity and inhibition assays were performed by monitoring the NADPH-dependent reduction of dihydrofolate catalyzed by the DHFR enzyme. The r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)