Compile Data Set for Download or QSAR
Report error Found 193 Enz. Inhib. hit(s) with all data for entry = 9743
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485761BDBM485761((R)-N-methyl-3-((1- methylisoquinolin-5- yl)oxy)-3...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485755BDBM485755((R)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485784BDBM485784(US10941138, Example 83 | (S)-3-(3-Fluorothiophen-2...)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485754BDBM485754((R)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485780BDBM485780((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485747BDBM485747(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485752BDBM485752((S)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485711BDBM485711((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485707BDBM485707(N-ethyl-3-(isoquinolin-5- yloxy)-3-(thiophen-2- yl...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485748BDBM485748(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485747BDBM485747(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485768BDBM485768((R)-3-((2,4- dimethylquinolin-5- yl)oxy)-N-methyl-...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485744BDBM485744(3-(5-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485764BDBM485764((R)-N-methyl-3-((1- methylisoquinolin-8- yl)oxy)-3...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485791BDBM485791((R)-5-(3-(ethylamino)-1- (thiophen-2- yl)propoxy)i...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485758BDBM485758(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiophen-3- y...)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485755BDBM485755((R)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485754BDBM485754((R)-3-(5-fluorothiophen-2- yl)-3-(isoquinolin-5-yl...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485718BDBM485718(5-(3-(methylamino)-1- (thiophen-2- yl)propoxy)isoq...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485780BDBM485780((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485744BDBM485744(3-(5-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485713BDBM485713((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485711BDBM485711((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-2- ...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485705BDBM485705(3-(isoquinolin-5-yloxy)- N-methyl-3-(thiophen-2- y...)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485770BDBM485770((S)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485692BDBM485692(US10941138, Example 1)
Affinity DataKi: <100nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485764BDBM485764((R)-N-methyl-3-((1- methylisoquinolin-8- yl)oxy)-3...)
Affinity DataKi: <100nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485788BDBM485788(US10941138, Example 87 | (S)-3-(3-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485762BDBM485762((R)-3-(isoquinolin-5- yloxy)-N-methyl-3- (thiophen...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485786BDBM485786(US10941138, Example 85 | (S)-3-(3-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485760BDBM485760(3-(isoquinolin-8-yloxy)-N- methyl-3-(thiophen-3- y...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485759BDBM485759(N-methyl-3-(quinolin-5- yloxy)-3-(thiophen-3- yl)p...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485786BDBM485786(US10941138, Example 85 | (S)-3-(3-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485758BDBM485758(3-(isoquinolin-5-yloxy)-N- methyl-3-(thiophen-3- y...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485784BDBM485784(US10941138, Example 83 | (S)-3-(3-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485784BDBM485784(US10941138, Example 83 | (S)-3-(3-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485782BDBM485782(US10941138, Example 81 | (S)-3-(5-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485753BDBM485753((S)-3-(5-fluorothiophen-2- yl)-N-methyl-3-(quinoli...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485782BDBM485782(US10941138, Example 81 | (S)-3-(5-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485751BDBM485751(3-(5-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485750BDBM485750(3-(3-fluorothiophen-2-yl)- N-methyl-3-(quinolin-5-...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485749BDBM485749(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-8-yloxy)...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485780BDBM485780((S)-3-(5-Chlorothiophen-2-yl)-N-methyl-3-(quinolin...)
Affinity DataKi:  300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485748BDBM485748(3-(3-fluorothiophen-2-yl)- 3-(isoquinolin-5-yloxy)...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485778BDBM485778(US10941138, Example 77 | (S) N-Methyl-3-(quinolin-...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485777BDBM485777(US10941138, Example 75)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485774BDBM485774(N-methyl-3-(quinolin-5- yloxy)-3-(thiazol-2- yl)pr...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485769BDBM485769((S)-N-methyl-3-(quinolin- 5-yloxy)-3-(thiophen-3- ...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetNeuroepithelial cell-transforming gene 1 protein(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485796BDBM485796((R)-N-methyl-3-(quinolin- 3-yloxy)-3-(thiophen-2- ...)
Affinity DataKi:  300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 485788BDBM485788(US10941138, Example 87 | (S)-3-(3-Fluorothiophen-2...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
US Patent

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