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Found 21 Enz. Inhib. hit(s) with all data for entry = 10189
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518793(6-Butoxy-1-(3-(piperidin-1-ylmethyl)benzyl)-1H-pyr...)
Affinity DataIC50:  3.00E+3nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518790(6-Butoxy-1-(4-(piperidin-1-ylmethyl)benzyl)-1H-pyr...)
Affinity DataIC50:  3.00E+3nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518783(6-Butoxy-1-(4-(pyrrolidin-1-ylmethyl)benzyl)-1H-py...)
Affinity DataIC50:  4.00E+3nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518790(6-Butoxy-1-(4-(piperidin-1-ylmethyl)benzyl)-1H-pyr...)
Affinity DataIC50:  4.00E+3nMAssay Description:Test Example 5: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518792(6-Butoxy-1-(3-(pyrrolidin-1-ylmethyl)benzyl)-1H-py...)
Affinity DataIC50:  6.00E+3nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518790(6-Butoxy-1-(4-(piperidin-1-ylmethyl)benzyl)-1H-pyr...)
Affinity DataIC50:  7.00E+3nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518793(6-Butoxy-1-(3-(piperidin-1-ylmethyl)benzyl)-1H-pyr...)
Affinity DataIC50:  1.00E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518793(6-Butoxy-1-(3-(piperidin-1-ylmethyl)benzyl)-1H-pyr...)
Affinity DataIC50:  1.00E+4nMAssay Description:Test Example 5: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518789(1-(4-(Azetidin-1-ylmethyl)benzyl)-6-butoxy-1H-pyra...)
Affinity DataIC50:  1.00E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518792(6-Butoxy-1-(3-(pyrrolidin-1-ylmethyl)benzyl)-1H-py...)
Affinity DataIC50:  1.10E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518783(6-Butoxy-1-(4-(pyrrolidin-1-ylmethyl)benzyl)-1H-py...)
Affinity DataIC50:  1.40E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518796(1-(4-Amino-1-(4-pyrrolidin-1-ylmethyl)benzyl)-1H-p...)
Affinity DataIC50:  1.60E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518792(6-Butoxy-1-(3-(pyrrolidin-1-ylmethyl)benzyl)-1H-py...)
Affinity DataIC50:  1.60E+4nMAssay Description:Test Example 5: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518796(1-(4-Amino-1-(4-pyrrolidin-1-ylmethyl)benzyl)-1H-p...)
Affinity DataIC50:  1.60E+4nMAssay Description:Test Example 5: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518789(1-(4-(Azetidin-1-ylmethyl)benzyl)-6-butoxy-1H-pyra...)
Affinity DataIC50:  1.90E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518796(1-(4-Amino-1-(4-pyrrolidin-1-ylmethyl)benzyl)-1H-p...)
Affinity DataIC50: >3.00E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518789(1-(4-(Azetidin-1-ylmethyl)benzyl)-6-butoxy-1H-pyra...)
Affinity DataIC50: >3.00E+4nMAssay Description:Test Example 5: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518783(6-Butoxy-1-(4-(pyrrolidin-1-ylmethyl)benzyl)-1H-py...)
Affinity DataIC50: >3.00E+4nMAssay Description:Test Example 5: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518794(6-(2-Methoxyethoxy)-1-(4-(pyrrolidin-1-ylmethyl)be...)
Affinity DataIC50: >3.00E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518794(6-(2-Methoxyethoxy)-1-(4-(pyrrolidin-1-ylmethyl)be...)
Affinity DataIC50: >3.00E+4nMAssay Description:Test Example 4: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM518794(6-(2-Methoxyethoxy)-1-(4-(pyrrolidin-1-ylmethyl)be...)
Affinity DataIC50: >3.00E+4nMAssay Description:Test Example 5: 100 mM PBS buffer was formulated, which was then used to formulate 2.5 mg/ml microsome solution and 5 mM NADPH solution. The 5× conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent