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Found 18 Enz. Inhib. hit(s) with all data for entry = 10300
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525857(US11174262, Example 1)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525874(US11174262, Example 18)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525859(US11174262, Example 3)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525860(3-(3,4-difluorophenyl)-6,6-dimethyl-1,2,3,7,8,9-he...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525861(3-(3-fluorophenyl)-6,6-dimethyl-1,2,3,7,8,9-hexahy...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525862(3-(6,6-dimethyl-5-oxo-1,2,3,7,8,9-hexahydropyrazol...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525863(4-(6,6-dimethyl-5-oxo-1,2,3,7,8,9-hexahydropyrazol...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525858(6,6-dimethyl-3-(5-methylpyrazin-2-yl)-1,2,3,7,8,9-...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525873(6-(difluoromethyl)-6-ethyl-3-(5-methylpyrazin-2-yl...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525865(5-(6,6-dimethyl-5-oxo-1,2,3,7,8,9-hexahydropyrazol...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525866(6-(difluoromethyl)-3-(5-fluoro-3-pyridyl)-6-methyl...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525867(6-(difluoromethyl)-3-(5-fluoro-3-pyridyl)-6-methyl...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525868(6-(difluoromethyl)-6-methyl-3-(5-methylpyrazin-2-y...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525869(6-(difluoromethyl)-6-methyl-3-(5-methylpyrazin-2-y...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525870(5-[6-(difluoromethyl)-6-methyl-5-oxo-1,2,3,7,8,9-h...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525871(5-[6-(difluoromethyl)-6-methyl-5-oxo-1,2,3,7,8,9-h...)
Affinity DataIC50: <1.00E+3nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525872(3-(5-fluoro-3-pyridyl)spiro[1,2,3,7,8,9-hexahydrop...)
Affinity DataIC50:  1.55E+4nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Denali Therapeutics

US Patent
LigandPNGBDBM525864((7S,9aR)-4-ethyl-7-(3-fluorophenyl)-4-methyl-1,3,7...)
Affinity DataIC50:  1.55E+4nMAssay Description:Test compounds were serially diluted in DMSO at 100 fold final concentrations in the assay (1% DMSO final). In each well of a 384-well Plate were dis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent