Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 10971
TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581678BDBM581678((2s,4S)-N-((1s,3S)-3-(4-Isopropylphenyl)cyclobutyl...)
Affinity DataIC50: 0.0400nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581668BDBM581668((2s,4S)-N-((1s,3S)-3-(4-(tert-Butyl)phenyl)cyclobu...)
Affinity DataIC50: 0.200nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581697BDBM581697((2s,4S)-N-((1s,3S)-3-(4-Cyclopropyl-3-methylphenyl...)
Affinity DataIC50: 0.25nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581706BDBM581706((2s,4S)-N-Methyl-N-((1s,3S)-3-(4-(1-methylcyclopro...)
Affinity DataIC50: 0.25nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581679BDBM581679((2s,4S)-N-((1s,3S)-3-(3-(tert-Butyl)-4-fluoropheny...)
Affinity DataIC50: 0.390nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581710BDBM581710(US11512059, Example 44 | (2s,4S)-N-((1s,3S)-3-(3-C...)
Affinity DataIC50: 0.520nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581680BDBM581680((2s,4S)-N-Methyl-6-oxo-N-((1s,3S)-3-(3-(1- | US115...)
Affinity DataIC50: 0.600nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581696BDBM581696((2s,4S)-N-((1s,3S)-3-(4-Ethyl-3-methylphenyl)cyclo...)
Affinity DataIC50: 0.800nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581707BDBM581707((2s,4S)-N-((1s,3S)-3-(4-(Sec-butyl)phenyl)cyclobut...)
Affinity DataIC50: 0.820nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581671BDBM581671((2s,4S)-N-((1s,3S)-3-(3-(tert-Butyl)phenyl)cyclobu...)
Affinity DataIC50: 0.840nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581698BDBM581698((2s,4S)-N-((1s,3S)-3-(3-Cyclopropyl-4-methylphenyl...)
Affinity DataIC50: 0.900nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581711BDBM581711(US11512059, Example 45 | (2s,4S)-N-((1s,3S)-3-(3-I...)
Affinity DataIC50: 0.950nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581693BDBM581693((2s,4S)-N-((1s,3S)-3-(4-Fluoro-3-isopropylphenyl)c...)
Affinity DataIC50: 0.950nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581692BDBM581692((2s,4S)-N-((1s,3S)-3-(3-Fluoro-4-isopropylphenyl)c...)
Affinity DataIC50: 1nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581708BDBM581708((2s,4S)-N-Methyl-N-((1s,3S)-3-(3-(1-methylcyclopro...)
Affinity DataIC50: 1.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581714BDBM581714(US11512059, Example 48 | (2s,4S)-N-((1s,3S)-3-(2,3...)
Affinity DataIC50: 1.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581681BDBM581681((2s,4S)-N-Methyl-6-oxo-N-((1r,3R)-3-(3-(1- | US115...)
Affinity DataIC50: 1.40nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581699BDBM581699((2s,4S)-N-Methyl-6-oxo-N-((1s,3S)-3-(5,6,7,8-tetra...)
Affinity DataIC50: 1.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581675BDBM581675((2s,4S)-N-((1s,3S)-3-(3-Isopropylphenyl)cyclobutyl...)
Affinity DataIC50: 1.80nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581667BDBM581667((2s,4S)-N-((1s,3S)-3-(3-Cyclobutylphenyl)cyclobuty...)
Affinity DataIC50: 1.90nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581690BDBM581690((2s,4S)-N-((1s,3S)-3-(4-Cyclopropylphenyl)cyclobut...)
Affinity DataIC50: 2nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581695BDBM581695((2s,4S)-N-((1s,3S)-3-(4-Ethylphenyl)cyclobutyl)-N-...)
Affinity DataIC50: 2.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581709BDBM581709((2s,4S)-N-((1s,3S)-3-(3-Ethyl-5-methylphenyl)cyclo...)
Affinity DataIC50: 2.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581713BDBM581713(US11512059, Example 47 | (2s,4S)-N-((1s,3S)-3-(3-C...)
Affinity DataIC50: 2.30nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581715BDBM581715(US11512059, Example 49 | (2s,4S)-N-((1s,3S)-3-(Bic...)
Affinity DataIC50: 2.60nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581691BDBM581691((2s,4S)-N-((1s,3S)-3-(3,4-Dimethylphenyl)cyclobuty...)
Affinity DataIC50: 3.60nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581704BDBM581704((2s,4S)-N-((1s,3S)-3-Cyclohexylcyclobutyl)-N-methy...)
Affinity DataIC50: 4nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581712BDBM581712(US11512059, Example 46 | (2s,4S)-N-((1s,3S)-3-(3-C...)
Affinity DataIC50: 4.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581673BDBM581673((2s,4S)-N-((1s,3S)-3-(3,5-Dimethylphenyl)cyclobuty...)
Affinity DataIC50: 4.80nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581672BDBM581672((2r,4S)-N-((1s,3S)-3-(3-(tert-Butyl)phenyl)cyclobu...)
Affinity DataIC50: 5.10nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581688BDBM581688((2s,4S)-N-((1s,3S)-3-(2,3-Dimethylphenyl)cyclobuty...)
Affinity DataIC50: 5.89nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581687BDBM581687((2s,4S)-N-((1s,3S)-3-(3-Ethylphenyl)cyclobutyl)-N-...)
Affinity DataIC50: 6nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581669BDBM581669((2s,4S)-N-((1r,3R)-3-(4-(tert-Butyl)phenyl)cyclobu...)
Affinity DataIC50: 6.90nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581700BDBM581700((2s,4S)-N-((1r,3S)-3-Benzylcyclobutyl)-N-methyl-6-...)
Affinity DataIC50: 7.80nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581694BDBM581694((2s,4S)-N-((1s,3S)-3-(2,4-Dimethylphenyl)cyclobuty...)
Affinity DataIC50: 8.20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581684BDBM581684((2s,4S)-N-Methyl-6-oxo-N-((1s,3S)-3-(m-tolyl)cyclo...)
Affinity DataIC50: 11nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581705BDBM581705((2s,4S)-N-((1r,3R)-3-Cyclohexylcyclobutyl)-N-methy...)
Affinity DataIC50: 20nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581676BDBM581676((2s,4S)-N-((1s,3S)-3-(3-Methoxyphenyl)cyclobutyl)-...)
Affinity DataIC50: 50nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581716BDBM581716(US11512059, Example 50 | (2s,4S)-N-((1s,3S)-3-(3,5...)
Affinity DataIC50: 54nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581701BDBM581701((2s,4S)-N-((1s,3R)-3-Benzylcyclobutyl)-N-methyl-6-...)
Affinity DataIC50: 70.7nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581682BDBM581682((2s,4S)-N-Methyl-6-oxo-N-((1s,3S)-3-(o-tolyl)cyclo...)
Affinity DataIC50: 74nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581702BDBM581702((2s,4S)-N-((1s,3S)-3-(tert-Butyl)cyclobutyl)-N-met...)
Affinity DataIC50: 76nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581665BDBM581665((2s,4S)-N-Methyl-6-oxo-N-((1s,3S)-3-phenylcyclobut...)
Affinity DataIC50: 78nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581689BDBM581689((2s,4S)-N-((1r,3R)-3-(2,3-Dimethylphenyl)cyclobuty...)
Affinity DataIC50: 116nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581674BDBM581674((2s,4S)-N-((1r,3R)-3-(3,5-Dimethylphenyl)cyclobuty...)
Affinity DataIC50: 130nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581685BDBM581685((2s,4S)-N-Methyl-6-oxo-N-((1r,3R)-3-(m-tolyl)cyclo...)
Affinity DataIC50: 166nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581666BDBM581666((2s,4S)-N-Methyl-6-oxo-N-((1r,3R)-3-phenylcyclobut...)
Affinity DataIC50: 286nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581683BDBM581683((2s,4S)-N-Methyl-6-oxo-N-((1r,3R)-3-(o-tolyl)cyclo...)
Affinity DataIC50: 417nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581703BDBM581703((2s,4S)-N-((1r,3R)-3-(tert-Butyl)cyclobutyl)-N-met...)
Affinity DataIC50: 512nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 581677BDBM581677((2s,4S)-N-((1r,3R)-3-(3-Methoxyphenyl)cyclobutyl)-...)
Affinity DataIC50: 678nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent