Compile Data Set for Download or QSAR
Report error Found 154 Enz. Inhib. hit(s) with all data for entry = 11231
TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492945BDBM492945(US10981905, Example 18 | 6-(difluoromethyl)-5-((2-...)
Affinity DataIC50: 15nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 493000BDBM493000(US10981905, Example 48 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 17nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492999BDBM492999(US10981905, Example 47 | 5-((2-((7-azabicyclo[2.2....)
Affinity DataIC50: 21nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492947BDBM492947(US10981905, Example 20 | 5-((2-(azetidin-1-ylmethy...)
Affinity DataIC50: 23nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 601714BDBM601714(US11639351, Example 35 | 3-fluoro-5-((2-fluoro-6- ...)
Affinity DataIC50: 24nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492912BDBM492912(US10981905, Example 4 | 5-((2-(azetidin-1-ylmethyl...)
Affinity DataIC50: 26nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492962BDBM492962(US10981905, Example 33 | 5-((2-((azabicyclo[2.2.1]...)
Affinity DataIC50: 37nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 601713BDBM601713(US11639351, Example 34 | 5-((2-((tert- butyl(methy...)
Affinity DataIC50: 37nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492946BDBM492946(US10981905, Example 19 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 38nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 601708BDBM601708(US11639351, Example 29 | 5-((2-fluoro-6- ((isoprop...)
Affinity DataIC50: 39nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492948BDBM492948(US10981905, Example 21 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 43nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492971BDBM492971(US10981905, Example 41 | 5-((2-fluoro-6-(pyrrolidi...)
Affinity DataIC50: 56nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492947BDBM492947(US10981905, Example 20 | 5-((2-(azetidin-1-ylmethy...)
Affinity DataIC50: 67nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492915BDBM492915(US10981905, Example 6 | 5-((2-((tert-butyl(methyl)...)
Affinity DataIC50: 69nMAssay Description:Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492951BDBM492951(US10981905, Example 24 | 5-((2-fluoro-6-((3-methyl...)
Affinity DataIC50: 74nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 493001BDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 78nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 601708BDBM601708(US11639351, Example 29 | 5-((2-fluoro-6- ((isoprop...)
Affinity DataIC50: 82nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 493000BDBM493000(US10981905, Example 48 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 84nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492948BDBM492948(US10981905, Example 21 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 102nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492959BDBM492959(US10981905, Example 30 | 5-(5-((2-fluoro-6-(pyrrol...)
Affinity DataIC50: 111nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492912BDBM492912(US10981905, Example 4 | 5-((2-(azetidin-1-ylmethyl...)
Affinity DataIC50: 111nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492952BDBM492952(US10981905, Example 25 | 5-((2-((7-azabicyclo[2.2....)
Affinity DataIC50: 154nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492986BDBM492986(US10981905, Example 44 | 5-((3,6-difluoro-2-(pyrro...)
Affinity DataIC50: 171nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492949BDBM492949(US10981905, Example 22 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 221nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492946BDBM492946(US10981905, Example 19 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 221nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492953BDBM492953(US10981905, Example 26 | 5-((2-(azetidin-1-ylmethy...)
Affinity DataIC50: 242nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492965BDBM492965(US10981905, Example 36 | 5-((2-bromo-3,6-difluorob...)
Affinity DataIC50: 245nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492961BDBM492961(US10981905, Example 32 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 272nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492941BDBM492941(US10981905, Example 15 | 5-((2-(((cyclopropylmethy...)
Affinity DataIC50: 286nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492954BDBM492954(US10981905, Example 27 | 5-((2-(azetidin-1-ylmethy...)
Affinity DataIC50: 296nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492937BDBM492937(US10981905, Example 14 | 5-((2-fluoro-6-((3-fluoro...)
Affinity DataIC50: 382nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492915BDBM492915(US10981905, Example 6 | 5-((2-((tert-butyl(methyl)...)
Affinity DataIC50: 398nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492917BDBM492917(US10981905, Example 8 | 5-((2-((2,2-dimethylazetid...)
Affinity DataIC50: 719nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 601707BDBM601707(US11639351, Example 28 | 5-((2-((tert- butyl(methy...)
Affinity DataIC50: 782nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492965BDBM492965(US10981905, Example 36 | 5-((2-bromo-3,6-difluorob...)
Affinity DataIC50: 863nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492918BDBM492918(US10981905, Example 9 | 5-((2-(azetidin-1-ylmethyl...)
Affinity DataIC50: 917nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492942BDBM492942(US10981905, Example 16 | 5-((isoquinolin-8-ylmethy...)
Affinity DataIC50: 1.27E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492943BDBM492943(US10981905, Example 17 | 4-(difluoromethyl)-5-((2-...)
Affinity DataIC50: 1.46E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492960BDBM492960(US10981905, Example 31 | 5-((2-(azetidin-1-ylmethy...)
Affinity DataIC50: 1.50E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 601725BDBM601725(US11639351, Example 46 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 1.78E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492989BDBM492989(US10981905, Example 45 | 3-fluoro-5-((2-fluoro-6-(...)
Affinity DataIC50: 1.93E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492973BDBM492973(US10981905, Example 43 | 5-((2-fluoro-6-(pyrrolidi...)
Affinity DataIC50: 2.11E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492970BDBM492970(US10981905, Example 40 | 6-((2-fluoro-6-(pyrrolidi...)
Affinity DataIC50: 2.23E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492969BDBM492969(US10981905, Example 39 | 5-((2-fluoro-6-(pyrrolidi...)
Affinity DataIC50: 2.68E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492907BDBM492907(US10981905, Example 1 | (S)-5-chloro-6-((1-(5-chlo...)
Affinity DataIC50: 2.82E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492967BDBM492967(US10981905, Example 38 | 5-((2-fluoro-6-(pyrrolidi...)
Affinity DataIC50: 3.14E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492970BDBM492970(US10981905, Example 40 | 6-((2-fluoro-6-(pyrrolidi...)
Affinity DataIC50: 3.27E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492916BDBM492916(US11639351, Example 7 | US10981905, Example 7 | 5-...)
Affinity DataIC50: 3.43E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 493001BDBM493001(US10981905, Example 49 | 5-((2-((tert-butyl(methyl...)
Affinity DataIC50: 3.75E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 492972BDBM492972(US10981905, Example 42 | 5-chloro-6-((2-fluoro-6-(...)
Affinity DataIC50: 4.47E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
US Patent

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