Compile Data Set for Download or QSAR
Report error Found 1392 Enz. Inhib. hit(s) with all data for entry = 11863
LigandChemical structure of BindingDB Monomer ID 50117930BDBM50117930(N-(4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidi...)
Affinity DataIC50: 13nMAssay Description:The standard Automated Qpatch patch-clamp assay have been used and the selective hERG inhibitor E4031, serves as a positive control.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654816BDBM654816(US11912693, Compound 429 | 7-bromo-2-(1-isopropyl-...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654817BDBM654817(US11912693, Compound 430 | N-[(4Z)-2,2-diethyl-6-[...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654814BDBM654814(US11912693, Compound 427 | 4-chloro-2-(1-isopropyl...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654815BDBM654815(US11912693, Compound 428 | 4-bromo-2-(1-isopropylb...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654820BDBM654820(US11912693, Compound 433 | 5-[4-(2-methylphenyl)-1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654821BDBM654821(US11912693, Compound 434 | 4-[1-(propan-2-yl)-1H-1...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654818BDBM654818(US11912693, Compound 431 | N-[(4E)-2,2-diethyl-6-[...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654819BDBM654819(US11912693, Compound 432 | 1-(propan-2-yl)-5-{4-[2...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654808BDBM654808(US11912693, Compound 421 | 2-(1-isopropyl-1H- benz...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654809BDBM654809(US11912693, Compound 422 | 2-(isopropylamino)-5-(3...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654806BDBM654806(US11912693, Compound 419 | 2-(1-isopropyl-1H- benz...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654807BDBM654807(US11912693, Compound 420 | 2-(1-isopropyl-1H- benz...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654812BDBM654812(US11912693, Compound 425 | 2-(1-isopropyl-1H- benz...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654813BDBM654813(US11912693, Compound 426 | 2-(1-isopropyl-1H- benz...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654810BDBM654810(US11912693, Compound 423 | 2-((cyclopropylmethyl)a...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654811BDBM654811(US11912693, Compound 424 | 2-(1-isopropyl-1H- benz...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654832BDBM654832(US11912693, Compound 445 | 6-(5-(2,2-diethyl-4-oxo...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654833BDBM654833(US11912693, Compound 446 | 6-(3-(2-aminobenzo[d]th...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654830BDBM654830(US11912693, Compound 443 | 5-(3-(2,2-diethyl-4-oxo...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654831BDBM654831(US11912693, Compound 444 | 2-((cyclopropylmethyl)a...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654836BDBM654836(US11912693, Compound 449 | 2-(1-isobutyl-1H- benzo...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654837BDBM654837(US11912693, Compound 450 | 2-(1-isobutyl-1H- benzo...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654834BDBM654834(US11912693, Compound 447 | 2-(1-isobutyl-1H- benzo...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654835BDBM654835(US11912693, Compound 448 | 2-(1-isobutyl-1H- benzo...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654824BDBM654824(US11912693, Compound 437 | 2-(1-isobutyl-1H- benzo...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654825BDBM654825(US11912693, Compound 438 | 2-{2-[1-(propan-2-yl)-1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654822BDBM654822(US11912693, Compound 435 | 2-(isopropylamino)-5-(3...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654823BDBM654823(US11912693, Compound 436 | 2-(1-isopropyl-1H- benz...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654828BDBM654828(US11912693, Compound 441 | 5-(3-(2-aminobenzo[d]th...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654829BDBM654829(US11912693, Compound 442 | 2-(isopropylamino)-5-(3...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654826BDBM654826(US11912693, Compound 439 | 5-[3-(4-methylpyridin-3...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654827BDBM654827(US11912693, Compound 440 | 5-(3-(2-aminobenzo[d]th...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654848BDBM654848(US11912693, Compound 461 | 4-bromo-2-(1-isobutyl-1...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654849BDBM654849(US11912693, Compound 462 | 5-{4H-chromeno[4,3-d][1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654846BDBM654846(US11912693, Compound 459 | 1-(propan-2-yl)-5-[4-(t...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654847BDBM654847(US11912693, Compound 460 | 2-methyl-1-(5-{3-[3- (t...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654852BDBM654852(US11912693, Compound 465 | 2,2-diethyl-6-(3-(furan...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654853BDBM654853(US11912693, Compound 466 | 6-(3-(1H-imidazol-5-yl)...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654850BDBM654850(US11912693, Compound 463 | 5-[4-(3-chlorothiophen-...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654851BDBM654851(US11912693, Compound 464 | 6-(3-(1H-pyrrol-2-yl)-1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654840BDBM654840(US11912693, Compound 453 | 4-chloro-2-(1-isobutyl-...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654841BDBM654841(US11912693, Compound 454 | 7-bromo-2-(1-isobutyl-1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654838BDBM654838(US11912693, Compound 451 | 2-(1-isobutyl-1H- benzo...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654839BDBM654839(US11912693, Compound 452 | 2-(1-isobutyl-1H- benzo...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654844BDBM654844(US11912693, Compound 457 | 4-[1-(propan-2-yl)-1H-1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654845BDBM654845(US11912693, Compound 458 | N-(2-{2-[1-(propan-2-yl...)
Affinity DataEC50: >316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654842BDBM654842(US11912693, Compound 455 | 1-(propan-2-yl)-5-{3-[3...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654843BDBM654843(US11912693, Compound 456 | 4-[1-(propan-2-yl)-1H-1...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Trevena

US Patent
LigandChemical structure of BindingDB Monomer ID 654864BDBM654864(US11912693, Compound 477 | 2-[(2,2-difluoroethyl)a...)
Affinity DataEC50: <316nMAssay Description:Agonist-promoted G-protein responses were determined by measuring changes in intracellular cAMP using the HTRF cAMP HiRange kit (CisBio, Cat #: 62AM6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

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