Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 12247
TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689584(US12054497, Compound Z50-2 | US12054497, Compound ...)
Affinity DataIC50: 8nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
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TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689570(US12054497, Compound Z27-2 | US12054497, Compound ...)
Affinity DataIC50: 9nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689578(US12054497, Compound Z37-2 | US12054497, Compound ...)
Affinity DataIC50: 11nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
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TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689583(US12054497, Compound Z50)
Affinity DataIC50: 19nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
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TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689577(US12054497, Compound Z37)
Affinity DataIC50: 20nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689564(US12054497, Compound Z25-2)
Affinity DataIC50: 25nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689569(US12054497, Compound Z27)
Affinity DataIC50: 27nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689566(US12054497, Compound Z26)
Affinity DataIC50: 34nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689554(US12054497, Compound Z10-2 | US12054497, Compound ...)
Affinity DataIC50: 37nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689561(US12054497, Compound Z24-2 | US12054497, Compound ...)
Affinity DataIC50: 38nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689568(US12054497, Compound Z26-2)
Affinity DataIC50: 40nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689580(US12054497, Compound Z38-2 | US12054497, Compound ...)
Affinity DataIC50: 53nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689560(US12054497, Compound Z24)
Affinity DataIC50: 58nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689563(US12054497, Compound Z25)
Affinity DataIC50: 60nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689554(US12054497, Compound Z10-2 | US12054497, Compound ...)
Affinity DataIC50: 67nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689576(US12054497, Compound Z35)
Affinity DataIC50: 73nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689552(US12054497, Compound Z9-2 | US12054497, Compound Z...)
Affinity DataIC50: 115nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689573(US12054497, Compound Z31)
Affinity DataIC50: 151nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689549(US12054497, Compound Z1-1 | US12054497, Compound Z...)
Affinity DataIC50: 152nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689574(US12054497, Compound Z33-2 | US12054497, Compound ...)
Affinity DataIC50: 162nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689558(US12054497, Compound Z21-2 | US12054497, Compound ...)
Affinity DataIC50: 172nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689570(US12054497, Compound Z27-2 | US12054497, Compound ...)
Affinity DataIC50: 198nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689549(US12054497, Compound Z1-1 | US12054497, Compound Z...)
Affinity DataIC50: 255nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689561(US12054497, Compound Z24-2 | US12054497, Compound ...)
Affinity DataIC50: 291nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689557(US12054497, Compound Z21)
Affinity DataIC50: 388nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689574(US12054497, Compound Z33-2 | US12054497, Compound ...)
Affinity DataIC50: 515nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689572(US12054497, Compound Z30)
Affinity DataIC50: 656nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689554(US12054497, Compound Z10-2 | US12054497, Compound ...)
Affinity DataIC50: 708nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689567(US12054497, Compound Z26-1)
Affinity DataIC50: 868nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689565(US12054497, Compound Z25-1)
Affinity DataIC50: 951nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689549(US12054497, Compound Z1-1 | US12054497, Compound Z...)
Affinity DataIC50: 1.43E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689584(US12054497, Compound Z50-2 | US12054497, Compound ...)
Affinity DataIC50: 1.45E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689578(US12054497, Compound Z37-2 | US12054497, Compound ...)
Affinity DataIC50: 1.90E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689580(US12054497, Compound Z38-2 | US12054497, Compound ...)
Affinity DataIC50: 2.15E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689582(US12054497, Compound Z39-2)
Affinity DataIC50: 2.25E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689552(US12054497, Compound Z9-2 | US12054497, Compound Z...)
Affinity DataIC50: 2.57E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12C](Human)
Genfleet Therapeutics (Shanghai)Inc.

US Patent
LigandPNGBDBM689558(US12054497, Compound Z21-2 | US12054497, Compound ...)
Affinity DataIC50: 3.94E+3nMAssay Description:The effects of compounds on SOS1 catalyzed displacement of GDP by GTP on KRas proteins was examined by homogeneous time-resolved fluorescence (HTRF)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent