Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 12511
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281169(CHEMBL4173846 | US20240034730, Compound 1 | US1216...)
Affinity DataIC50: 1.20nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquin...)
Affinity DataIC50: 1.80nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281170(CHEMBL4165923 | US20240034730, Compound 2 | US1216...)
Affinity DataIC50: 4.30nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281171(CHEMBL4177202 | US20240034730, Compound 3 | US1216...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM707308(US12162877, Compound 10)
Affinity DataIC50: 43nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50235593(CHEMBL4062046 | US12162877, Compound 2)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM707293(US12162877, Compound Teriflunomide)
Affinity DataIC50: 388nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281168(CHEMBL4167855 | US20240034730, Compound 27 | US121...)
Affinity DataIC50: 480nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281167(CHEMBL4175712 | US20240034730, Compound 38 | US121...)
Affinity DataIC50: 760nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery And Clinic

US Patent
LigandPNGBDBM50281173(CHEMBL4169359 | US12162877, Compound 7)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity was assessed by monitoring the reduction of 2,6-dichloroindophenol (DCIP), which is associated with the oxidation of dihydroorota...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2025
Entry Details
US Patent