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Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 12592
Target5-hydroxytryptamine receptor 2A(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM712632(US12195462, Example 1)
Affinity DataKi:  3nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM683053(US12023331, Example 1 | US20240307386, Compound Ex...)
Affinity DataKi:  8.30nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  10nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM712632(US12195462, Example 1)
Affinity DataKi:  10.2nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM683053(US12023331, Example 1 | US20240307386, Compound Ex...)
Affinity DataKi:  11nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  16nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetD(1A) dopamine receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM712632(US12195462, Example 1)
Affinity DataKi:  40nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetD(1A) dopamine receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  41nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi:  49nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetD(1A) dopamine receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM683053(US12023331, Example 1 | US20240307386, Compound Ex...)
Affinity DataKi:  50nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM712632(US12195462, Example 1)
Affinity DataKi:  114nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM683053(US12023331, Example 1 | US20240307386, Compound Ex...)
Affinity DataKi:  160nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM683053(US12023331, Example 1 | US20240307386, Compound Ex...)
Affinity DataKi:  590nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50556204(Lumateperone | ITI 007 | ITI-007 | ITI-722 | ITI00...)
Affinity DataKi: >1.00E+4nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Intra-Cellular Therapies

US Patent
LigandPNGBDBM712632(US12195462, Example 1)
Affinity DataKi: >1.00E+4nMAssay Description:Receptor binding is determined for the Compounds of Examples 1, 2 and 3 (corresponding to Formula 1, Formula B and Formula A, respectively). The foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent