Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 12726
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723377BDBM723377((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(7-(4-...)
Affinity DataIC50: 0.600nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723370BDBM723370((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 1.40nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723378BDBM723378((6-(4-fluoro-1H-pyrazol- 1-yl)pyridazin-3-yl)(3-(...)
Affinity DataIC50: 1.5nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723373BDBM723373((6-(4-chloro-1H-pyrazol- 1-yl)pyridazin-3-yl)(3-(...)
Affinity DataIC50: 1.70nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723387BDBM723387((6-(4-fluoro-1H-pyrazol- 1-yl)pyridazin-3-yl)(8-(...)
Affinity DataIC50: 1.80nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723383BDBM723383((6-(1-methyl-1H-pyrazol 4-yl)pyridazin-3-yl)(3-( ...)
Affinity DataIC50: 2nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723386BDBM723386([2,4'-bipyridin]-5-yl(3-(4- methyl-6-((5-methyl-1...)
Affinity DataIC50: 2.60nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723382BDBM723382((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 3nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723379BDBM723379((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 3.90nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723385BDBM723385((6-(4-fluorophenyl)pyridin- 3-yl)(3-(4-methyl-6-(...)
Affinity DataIC50: 5.60nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723371BDBM723371((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 6.20nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723375BDBM723375((6-(6,6-dimethyl-3-azabicyclo [3.1.0]hexane-3-yl)...)
Affinity DataIC50: 7.30nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723380BDBM723380((6-(4-fluoro-1H-pyrazol- 1-yl)pyridazin-3-yl)(3-(...)
Affinity DataIC50: 8nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723384BDBM723384((6-(1-methyl-1H-pyrazol- 4-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 8.10nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723374BDBM723374(1-(5-(8-(4-methyl-6-(5- methyl-1H-pyrazol-3-yl) ...)
Affinity DataIC50: 8.60nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723372BDBM723372((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(7-(4-...)
Affinity DataIC50: 10.3nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723369BDBM723369((S)-(6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(2...)
Affinity DataIC50: 11.8nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723368BDBM723368((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(4-(4-...)
Affinity DataIC50: 12.5nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723376BDBM723376(Methyl 2-(8-(6-(4-fluoro-1H- pyrazol-1-yl)nicoti...)
Affinity DataIC50: 24.7nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723381BDBM723381(2-(8-(6-(4-fluoro-1H- pyrazol-1-yl)nicotinoyl)-3,...)
Affinity DataIC50: 25.6nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 367752BDBM367752(US10227329, Compound 164 | US12234222, Compound 16...)
Affinity DataIC50: 73nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723378BDBM723378((6-(4-fluoro-1H-pyrazol- 1-yl)pyridazin-3-yl)(3-(...)
Affinity DataIC50: 78nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723370BDBM723370((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723387BDBM723387((6-(4-fluoro-1H-pyrazol- 1-yl)pyridazin-3-yl)(8-(...)
Affinity DataIC50: 95nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723373BDBM723373((6-(4-chloro-1H-pyrazol- 1-yl)pyridazin-3-yl)(3-(...)
Affinity DataIC50: 107nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723379BDBM723379((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 141nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723371BDBM723371((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 149nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723377BDBM723377((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(7-(4-...)
Affinity DataIC50: 180nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723383BDBM723383((6-(1-methyl-1H-pyrazol 4-yl)pyridazin-3-yl)(3-( ...)
Affinity DataIC50: 221nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723385BDBM723385((6-(4-fluorophenyl)pyridin- 3-yl)(3-(4-methyl-6-(...)
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723374BDBM723374(1-(5-(8-(4-methyl-6-(5- methyl-1H-pyrazol-3-yl) ...)
Affinity DataIC50: 304nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723384BDBM723384((6-(1-methyl-1H-pyrazol- 4-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 374nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723372BDBM723372((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(7-(4-...)
Affinity DataIC50: 391nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723386BDBM723386([2,4'-bipyridin]-5-yl(3-(4- methyl-6-((5-methyl-1...)
Affinity DataIC50: 467nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723380BDBM723380((6-(4-fluoro-1H-pyrazol- 1-yl)pyridazin-3-yl)(3-(...)
Affinity DataIC50: 738nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723369BDBM723369((S)-(6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(2...)
Affinity DataIC50: 851nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723376BDBM723376(Methyl 2-(8-(6-(4-fluoro-1H- pyrazol-1-yl)nicoti...)
Affinity DataIC50: 1.02E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723368BDBM723368((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(4-(4-...)
Affinity DataIC50: 1.13E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723375BDBM723375((6-(6,6-dimethyl-3-azabicyclo [3.1.0]hexane-3-yl)...)
Affinity DataIC50: 1.55E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723382BDBM723382((6-(4-fluoro-1H-pyrazol- 1-yl)pyridin-3-yl)(3-(4-...)
Affinity DataIC50: 1.55E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 367752BDBM367752(US10227329, Compound 164 | US12234222, Compound 16...)
Affinity DataIC50: 2.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 723381BDBM723381(2-(8-(6-(4-fluoro-1H- pyrazol-1-yl)nicotinoyl)-3,...)
Affinity DataIC50: 2.76E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent