Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 13222
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767726(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin...)
Affinity DataIC50: 0.130nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767725((1s,3s)-3-(3-amino-4-(6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 0.170nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767726(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridin...)
Affinity DataIC50: 0.25nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767727((1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 0.330nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767734((1r,3r)-3-(cyanomethyl)-3-(3-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 0.360nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767722(2-(3-(3-amino-4-(6-(1-methyl-TH-pyrazol-4-yl)pyraz...)
Affinity DataIC50: 0.380nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767736((1r,3r)-3-(cyanomethyl)-3-(5-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 0.410nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767721(4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-...)
Affinity DataIC50: 0.420nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767723(2-(3-(3-amino-4-(6-(1-methyl-1H-pyrazol-4-yl)pyraz...)
Affinity DataIC50: 2.10nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767728((1r,3r)-3-(cyanomethyl)-3-(3-(dimethylamino)-4-(6-...)
Affinity DataIC50: 3.70nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767727((1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 6.70nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767734((1r,3r)-3-(cyanomethyl)-3-(3-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 8.10nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767736((1r,3r)-3-(cyanomethyl)-3-(5-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 10nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM305821(US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...)
Affinity DataIC50: 11nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767725((1s,3s)-3-(3-amino-4-(6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 14nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767730((1r,3r)-3-(3-amino-4-(6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 37nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767732((is, 3s)-3-(3-amino-4-(6-(1-methyl-TH-pyrazol-4-yl...)
Affinity DataIC50: 43nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM305821(US10144738, Example 20 | (1r,3r)-3-(Cyanomethyl)-3...)
Affinity DataIC50: 47nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767722(2-(3-(3-amino-4-(6-(1-methyl-TH-pyrazol-4-yl)pyraz...)
Affinity DataIC50: 64nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767723(2-(3-(3-amino-4-(6-(1-methyl-1H-pyrazol-4-yl)pyraz...)
Affinity DataIC50: 77nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767721(4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-...)
Affinity DataIC50: 88nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767735((1s,3s)-3-(cyanomethyl)-3-(5-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 118nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767729(N-(1-((1r,3r)-3-cyano-1-(cyanomethyl)cyclobutyl)-4...)
Affinity DataIC50: 139nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767733((1s,3s)-3-(cyanomethyl)-3-(3-(6-(1-methyl-1H-pyraz...)
Affinity DataIC50: 186nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767728((1r,3r)-3-(cyanomethyl)-3-(3-(dimethylamino)-4-(6-...)
Affinity DataIC50: 200nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767731((1r,3r)-3-(3-amino-4-(6-(1-methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50: 375nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Primegene (Beijing) Co.

US Patent
LigandPNGBDBM767724(4-(3-amino-1-(3-(cyanomethyl)-1-(isopropylsulfonyl...)
Affinity DataIC50: 1.76E+3nMAssay Description:A compound (powder) was dissolved in 100% DMSO to prepare a 10 mM storage solution. The compound had an initial test concentration of 10,000 nM or 10...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/11/2025
Entry Details
US Patent