Compile Data Set for Download or QSAR
Report error Found 458 Enz. Inhib. hit(s) with all data for entry = 6201
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790213BDBM790213((S) or (R) 1-(4-{6-chloro-2-[(1- cyclopropyl-5-met...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790211BDBM790211((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50572913BDBM50572913(CHEMBL4868411 | US12540131, Ex-2.26)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 631071BDBM631071((3S,4S) or (3R,4R) 4-[4-(2-{[1- (bicyclo[1.1.1]pen...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790244BDBM790244((S) or (R) 3-[3-(4-{6-chloro-2- [(1-cyclopropyl-5-...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790243BDBM790243((S) or (R) 3-[3-(4-{6-chloro-2- [(1-cyclopropyl-5-...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 639355BDBM639355(4-[4-(2-{[5-chloro-1-(2,2- difluorocyclopropyl)-1H...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790254BDBM790254((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 639354BDBM639354((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790253BDBM790253((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 639357BDBM639357((3S,4S) or (3R,4R) 4-(4-{2-[(5- chloro-1-cycloprop...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790355BDBM790355(N-[1-(bicyclo[1.1.1]pentan-1-yl)-5- chloro-1H-pyra...)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790354BDBM790354((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790255BDBM790255((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790249BDBM790249((S) or (R) 1-(4-{6-chloro-2-[(1- cyclopropyl-5-met...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 639353BDBM639353(6-chloro-N-{1-[3- (methoxymethyl)bicyclo[1.1.1] pe...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790351BDBM790351((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 639352BDBM639352(6-chloro-N-{1-[3- (methoxymethyl)bicyclo[1.1.1] pe...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790350BDBM790350((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652107BDBM652107((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790261BDBM790261((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652109BDBM652109((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652108BDBM652108((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790263BDBM790263((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652103BDBM652103((3S,4S) or (3R,4R) 4-(4-{2-[(1- cyclopropyl-5-meth...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790357BDBM790357(US12540131, Ex-8.40)
Affinity DataIC50: 0.631nMAssay Description:Cells of Chem3 Cell Line (HTS145C:Millipore) in which mGluR1 was stably expressed were adjusted to a density of 2×106/ml. 50 μl of the cells wer...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652105BDBM652105((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790259BDBM790259((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790270BDBM790270((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790269BDBM790269((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652117BDBM652117((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652116BDBM652116((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790271BDBM790271((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790266BDBM790266((R)(3S,4S)(3S,4S) or (R)(3S,4S)(3R,4R) or (R)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790265BDBM790265((3S,4S)(2S) or (3R,4R)(2S) 4-[4- {2-[(5-chloro-1-c...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790267BDBM790267((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764617BDBM764617(6-chloro-N-(5-chloro-1- cyclopropyl-1H-pyrazol-4-y...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790278BDBM790278((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652122BDBM652122({3-[4-({6-chloro-7-[1-(3- methyloxetan-3-yl)piperi...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764616BDBM764616(6-chloro-N-[5-chloro-1-(1- methylcyclopropyl)-1H-p...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790277BDBM790277((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652125BDBM652125(6-chloro-N-(1-{3-[(3,3- difluoroazetidin-1- yl)met...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764619BDBM764619(1-(5-chloro-4-((6-chloro-7-(1- (oxetan-3-yl-3-d)pi...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652124BDBM652124(6-chloro-N-(1-{3- [(dimethylamino)methyl]bicyclo [...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 764618BDBM764618(1-(5-chloro-4-((6-chloro-7-(1- (oxetan-3-yl-d5)pip...)
Affinity DataIC50: 0.631nMAssay Description:To assess phosphor-EGFR signaling, blots were probed with rabbit anti-Phospho-EGFR (Y1068) and mouse total anti-EGFR antibodies. Phospho-EGFR signal ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790279BDBM790279((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790276BDBM790276((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652120BDBM652120((3S,4S) or (3R,4R)4-(4-{6-chloro- 2-[(3-methyl-l,2...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 790275BDBM790275((3S,4S)(3S,4S) or (3S,4S)(3R,4R) or (3R,4R)(3S,4S)...)
Affinity DataIC50: 0.631nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652131BDBM652131((3S,4S) or (3R,4R) 4-(4-{6-chloro- 2-[(5-chloro-1-...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent

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