Compile Data Set for Download or QSAR
Report error Found 510 Enz. Inhib. hit(s) with all data for entry = 11463
TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50582290BDBM50582290(CHEMBL5082614 | US20230286958, Example 198)
Affinity DataIC50: 0.100nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50582291BDBM50582291(CHEMBL5078294 | US20230286958, Example 200)
Affinity DataIC50: 0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50582288BDBM50582288(CHEMBL5089406 | US20230286958, Example 136)
Affinity DataIC50: 0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50582287BDBM50582287(CHEMBL5079850 | US20230286958, Example 41)
Affinity DataIC50: 0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50582291BDBM50582291(CHEMBL5078294 | US20230286958, Example 200)
Affinity DataIC50: 0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50582290BDBM50582290(CHEMBL5082614 | US20230286958, Example 198)
Affinity DataIC50: 0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617940BDBM617940(US20230286958, Example 152 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617993BDBM617993(US20230286958, Example 205 | US20230286958, Exampl...)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617832BDBM617832(US20230286958, Example 44)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617993BDBM617993(US20230286958, Example 205 | US20230286958, Exampl...)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617989BDBM617989(US20230286958, Example 201 | US20230286958, Exampl...)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50582289BDBM50582289(CHEMBL5076760 | US20230286958, Example 155)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617991BDBM617991(US20230286958, Example 203 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618006BDBM618006(US20230286958, Example 218 | US20230286958, Exampl...)
Affinity DataIC50: 0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618017BDBM618017(US20230286958, Example 229 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.370nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618028BDBM618028(US20230286958, Example 240 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617955BDBM617955(US20230286958, Example 167 | US20230286958, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617989BDBM617989(US20230286958, Example 201 | US20230286958, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617970BDBM617970(US20230286958, Example 182 | US20230286958, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617802BDBM617802(US20230286958, Example 14 | US20230286958, Example...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617827BDBM617827(US20230286958, Example 39)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617898BDBM617898(US20230286958, Example 110 | US20230286958, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617998BDBM617998(US20230286958, Example 210 | US20230286958, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618014BDBM618014(US20230286958, Example 226)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618022BDBM618022(US20230286958, Example 234 | US20230286958, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617907BDBM617907(US20230286958, Example 119 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617914BDBM617914(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617867BDBM617867(US20230286958, Example 79 | 4-(3-Chloro-6-(difluor...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617915BDBM617915(US20230286958, Example 127 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617800BDBM617800(US20230286958, Example 12 | US20230286958, Example...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617982BDBM617982(US20230286958, Example 194 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617919BDBM617919(US20230286958, Example 131 | US20230286958, Exampl...)
Affinity DataIC50: 0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617836BDBM617836(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617929BDBM617929(US20230286958, Example 141 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617919BDBM617919(US20230286958, Example 131 | US20230286958, Exampl...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617888BDBM617888(US20230286958, Example 100 | US20230286958, Exampl...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617921BDBM617921(US20230286958, Example 133 | US20230286958, Exampl...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617854BDBM617854(US20230286958, Example 66 | 6-(3-Chloro-6-(difluor...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617998BDBM617998(US20230286958, Example 210 | US20230286958, Exampl...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618015BDBM618015(US20230286958, Example 227)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618031BDBM618031(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617892BDBM617892(US20230286958, Example 104 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617907BDBM617907(US20230286958, Example 119 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617911BDBM617911(US20230286958, Example 123 | US20230286958, Exampl...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617927BDBM617927(US20230286958, Example 139 | 6-(3-Chloro-6-cyano-2...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617846BDBM617846(US20230286958, Example 58 | US20230286958, Example...)
Affinity DataIC50: 0.600nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617876BDBM617876(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50: 0.700nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 618028BDBM618028(US20230286958, Example 240 | 6-(3-Chloro-6-(difluo...)
Affinity DataIC50: 0.700nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617804BDBM617804(US20230286958, Example 16 | US20230286958, Example...)
Affinity DataIC50: 0.700nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 617890BDBM617890(US20230286958, Example 102 | US20230286958, Exampl...)
Affinity DataIC50: 0.700nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

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