Compile Data Set for Download or QSAR
Report error Found 766 Enz. Inhib. hit(s) with all data for entry = 11480
TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620037BDBM620037(US20230295157, Example 362 | (3S,8aR*)-3-(5-(1H-py...)
Affinity DataIC50: 0.100nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619953BDBM619953(US20230295157, Example 277 | 6-(2-((3S,8aR)-7-(3-C...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620017BDBM620017(US20230295157, Example 341 | Methyl (4-(2-((3S,8aR...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619914BDBM619914(US20230295157, Example 238 | 5-(2-((3*S,8aR)-7-(3-...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619946BDBM619946(US20230295157, Example 270)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619887BDBM619887(US20230295157, Example 211 | 5-(5-Chloro-2-((3S,8a...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619925BDBM619925(US20230295157, Example 249 | N-(4-(2-((3S,8a*R)-7-...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619989BDBM619989(US20230295157, Example 313 | (3S)-3-(5-(3-Amino-1H...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620029BDBM620029(US20230295157, Example 354 | (3S,8aR)-3-(5-(6-Amin...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620045BDBM620045(US20230295157, Example 370 | N-(4-(2-((3S)-7-(3-ch...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619926BDBM619926(US20230295157, Example 250 | N-(4-(24(3S,8aS*)-7-(...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620030BDBM620030(US20230295157, Example 355 | Methyl (4-(2-((3S)-7-...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620044BDBM620044(US20230295157, Example 369 | N-(2-(2-((3S,8aR)-7-(...)
Affinity DataIC50: 0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619934BDBM619934(US20230295157, Example 258 | (3S)-7-[3-Chloro-2-fl...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620027BDBM620027(US20230295157, Example 352 | (3S,8aS)-3-(5-(6-Amin...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619761BDBM619761(US20230295157, Example 84)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619937BDBM619937(US20230295157, Example 261)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619805BDBM619805(US20230295157, Example 149 | US20230295157, Exampl...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619983BDBM619983(US20230295157, Example 307 | N-(2-(2-((3S,8aR)-7-(...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620047BDBM620047(US20230295157, Example 372 | (3S,8aR)-3-(5-(2-amin...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619968BDBM619968(US20230295157, Example 292 | 5-(2-((3S,8aS)-7-(3-C...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620016BDBM620016(US20230295157, Example 340 | Methyl (4-(2-((3S,8aS...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619957BDBM619957(US20230295157, Example 281 | 6-(2-((3S,8aR)-7-(3-C...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619973BDBM619973(US20230295157, Example 297 | 6-(2-((3S)-7-(3-Chlor...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619894BDBM619894(US20230295157, Example 218 | 4-(5-Chloro-2-((3S)-7...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619747BDBM619747(US20230295157, Example 69)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619987BDBM619987(US20230295157, Example 311 | 6-(2-((3S)-7-(3-Chlor...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619748BDBM619748(US20230295157, Example 70)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619988BDBM619988(US20230295157, Example 312 | 5-(2-((3S)-7-(3-Chlor...)
Affinity DataIC50: 0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620042BDBM620042(US20230295157, Example 367 | N-(4-(2-((3S,8aR)-7-(...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619946BDBM619946(US20230295157, Example 270)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619796BDBM619796((3*S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl-5-d)-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619796BDBM619796((3*S,8aR)-3-(5-(6-amino-2-fluoropyridin-3-yl-5-d)-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619805BDBM619805(US20230295157, Example 149 | US20230295157, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619869BDBM619869(US20230295157, Example 193)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619854BDBM619854(US20230295157, Example 178 | (3R,8aR)-7-(3-chloro-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619794BDBM619794(US20230295157, Example 118 | 6-(24(3*S,8a*R)-7-(3-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619810BDBM619810(US20230295157, Example 134 | (3S,8aR)-7-(3-chloro-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619858BDBM619858(US20230295157, Example 182 | 4-(2-((3S,8aR)-7-(3-c...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619906BDBM619906(US20230295157, Example 230 | (3S,8aR)-7-(3-Chloro-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620063BDBM620063(US20230295157, Example 390 | (3S,8aR)-7-(3-chloro-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619805BDBM619805(US20230295157, Example 149 | US20230295157, Exampl...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619941BDBM619941(US20230295157, Example 265)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetKallikrein-1(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619925BDBM619925(US20230295157, Example 249 | N-(4-(2-((3S,8a*R)-7-...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619830BDBM619830(US20230295157, Example 154 | (3S,8aR)-3-[5-(6-amin...)
Affinity DataIC50: 0.400nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619801BDBM619801((3S,8aR)-3-(4-(6-amino-2-fluoropyridin-3-yl-5-d)-1...)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619802BDBM619802(US20230295157, Example 126 | (3S,8aR)-3-(5-(2-amin...)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619767BDBM619767(US20230295157, Example 90)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 620023BDBM620023(US20230295157, Example 348 | 3S)-3-(5-(6-Amino-2-f...)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetCoagulation factor XI(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 619837BDBM619837(US20230295157, Example 161 | (3S)-7-(3-chloro-2-fl...)
Affinity DataIC50: 0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

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