Compile Data Set for Download or QSAR
Report error Found 140 Enz. Inhib. hit(s) with all data for entry = 12185
TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684846BDBM684846(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0400nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684825BDBM684825(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0400nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684823BDBM684823(3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluo...)
Affinity DataIC50: 0.0450nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684879BDBM684879(3-((R)-1-(5-(5-amino-3,4-difluoro-2-(trifluorometh...)
Affinity DataIC50: 0.0500nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684840BDBM684840(3-((R)-1-((S)-5-(3-amino-2-chloro-5-methyl-6-(trif...)
Affinity DataIC50: 0.0500nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684823BDBM684823(3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluo...)
Affinity DataIC50: 0.0530nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684829BDBM684829(4-(10-((R)-1-(3-aminopyrazin-2-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0600nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684830BDBM684830(3-((1R)-1-(5-(3-amino-2,4-difluoro-5- methyl-6-(tr...)
Affinity DataIC50: 0.0600nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684852BDBM684852(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0600nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684834BDBM684834(3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluo...)
Affinity DataIC50: 0.0600nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684820BDBM684820(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0670nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684880BDBM684880(3-((R)-1-((R)-5-(3-amino-2,4-difluoro-5-methyl-6-(...)
Affinity DataIC50: 0.0690nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684885BDBM684885(US20240228512, Example 601a)
Affinity DataIC50: 0.0700nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684829BDBM684829(4-(10-((R)-1-(3-aminopyrazin-2-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0700nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684840BDBM684840(3-((R)-1-((S)-5-(3-amino-2-chloro-5-methyl-6-(trif...)
Affinity DataIC50: 0.0700nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684821BDBM684821(3-((R)-1-(5-(5-amino-3-methyl-2- (trifluoromethyl)...)
Affinity DataIC50: 0.0800nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684835BDBM684835(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0800nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684820BDBM684820(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.0800nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684895BDBM684895(3-((R)-1-(5-(6-amino-5-fluoro-4-methyl-3-(trifluor...)
Affinity DataIC50: 0.0890nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684851BDBM684851(3-((R)-1-(5-(3-Amino-8- ethynylnaphthalen-1-yl)-4-...)
Affinity DataIC50: 0.0900nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684891BDBM684891(3-((1R)-1-(5-(3-amino-2,4-difluoro-5-methyl-6-(tri...)
Affinity DataIC50: 0.0900nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684866BDBM684866(5-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2-(trifluor...)
Affinity DataIC50: 0.0900nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684857BDBM684857(6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-4-fluoro-...)
Affinity DataIC50: 0.0990nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684819BDBM684819(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- | US2024...)
Affinity DataIC50: 0.100nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684827BDBM684827(3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluo...)
Affinity DataIC50: 0.100nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684821BDBM684821(3-((R)-1-(5-(5-amino-3-methyl-2- (trifluoromethyl)...)
Affinity DataIC50: 0.104nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684845BDBM684845(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.110nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684879BDBM684879(3-((R)-1-(5-(5-amino-3,4-difluoro-2-(trifluorometh...)
Affinity DataIC50: 0.110nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684868BDBM684868(5-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2-(trifluor...)
Affinity DataIC50: 0.110nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684822BDBM684822(3-((R)-1-(5-(3-amino-8- ethynylnaphthalen-1-yl)-4-...)
Affinity DataIC50: 0.110nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684852BDBM684852(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.114nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684819BDBM684819(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- | US2024...)
Affinity DataIC50: 0.114nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684844BDBM684844(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.120nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684889BDBM684889(6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-2-(((1R,7...)
Affinity DataIC50: 0.120nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684887BDBM684887(3-((1R)-1-(5-(3-amino-2,4-difluoro-5-methyl-6-(tri...)
Affinity DataIC50: 0.120nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684825BDBM684825(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.120nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684846BDBM684846(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.130nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684855BDBM684855(3-((R)-1-(5-(5-amino-4-fluoro-3-methyl-2- (trifluo...)
Affinity DataIC50: 0.130nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684822BDBM684822(3-((R)-1-(5-(3-amino-8- ethynylnaphthalen-1-yl)-4-...)
Affinity DataIC50: 0.133nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684875BDBM684875(US20240228512, Example 605)
Affinity DataIC50: 0.140nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684890BDBM684890(US20240228512, Example 615)
Affinity DataIC50: 0.140nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684851BDBM684851(3-((R)-1-(5-(3-Amino-8- ethynylnaphthalen-1-yl)-4-...)
Affinity DataIC50: 0.150nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684835BDBM684835(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.159nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684858BDBM684858(US20240228512, Example 626)
Affinity DataIC50: 0.160nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684842BDBM684842(3-((1R)-1-(5-(3-amino-2-fluoro-5-methyl- 6-(triflu...)
Affinity DataIC50: 0.160nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684889BDBM684889(6-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)-2-(((1R,7...)
Affinity DataIC50: 0.160nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684877BDBM684877(3-((1R)-1-(5-(3-amino-2,4-difluoro-6-(trifluoromet...)
Affinity DataIC50: 0.170nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684833BDBM684833(3-((1R)-1-(5-(3-amino-2-fluoro-5-methyl- 6-(triflu...)
Affinity DataIC50: 0.170nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684832BDBM684832(4-(10-((R)-1-(2-aminopyridin-3-yl)ethyl)- 4-fluoro...)
Affinity DataIC50: 0.170nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 684830BDBM684830(3-((1R)-1-(5-(3-amino-2,4-difluoro-5- methyl-6-(tr...)
Affinity DataIC50: 0.175nMAssay Description:Biochemical compound potencies were assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS G12D. The SOS1-promoted exchange o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

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